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©2010 Baishideng.
World J Gastroenterol. May 7, 2010; 16(17): 2146-2150
Published online May 7, 2010. doi: 10.3748/wjg.v16.i17.2146
Published online May 7, 2010. doi: 10.3748/wjg.v16.i17.2146
Table 1 Baseline characteristics of the study population (mean ± SD) n (%)
Variables | All patients (n = 229) | Group A (n = 157) | Group B (n = 72) | P value |
Age (yr) | 65.0 ± 9.3 | 65.0 ± 9.8 | 63.0 ± 9.5 | 0.080 |
Gender (M/F) | 171 (74.7)/ 58 (25.3) | 119 (76.0)/ 38 (24.0) | 52 (72.0)/20 (28.0) | 0.330 |
Etiology of cirrhosis | 0.200 | |||
Hepatitis C | 148 (64.6) | 106 (67.0) | 42 (58.3) | |
Hepatitis B | 37 (16.2) | 21 (14.0) | 16 (22.2) | |
Hepatitis B + C | 15 (6.6) | 7 (5.0) | 8 (11.1) | |
Non-viral | 29 (12.7) | 23 (14.0) | 6 (8.3) | |
Child-Pugh score | 0.005 | |||
A | 218 (95.2) | 154 (98.0) | 64 (89.0) | |
B | 11 (4.8) | 3 (2.0) | 8 (11.0) | |
C | 0 | |||
MELD score | 8.8 ± 1.5 | 8.5 ± 1.2 | 9.3 ± 1.9 | 0.001 |
Platelet count (× 103) | 139 ± 60 | 150 ± 60 | 115 ± 51 | 0.001 |
Esophageal varices | 63 (28.0) | 34 (22.0) | 29 (40.3) | 0.003 |
Table 2 Details of surgery performed in the two groups
Variables | All patients (n = 229) | Group A (n = 157) | Group B (n = 72) | P value |
Type of resection n (%) | 0.610 | |||
Minor | 219 (95.0) | 150 (95.5) | 69 (95.8) | |
Major | 10 (5.0) | 7 (4.5) | 3 (4.2) | |
Duration of surgery (mean ± SD) | 266 ± 99 | 261 ± 106 | 275 ± 83 | 0.320 |
i.o. blood transfusion [mL, median (range)] | 128.2 (0-1500) | 124.7 (0-1500) | 154.1 (0-1200) | 0.346 |
i.o. FFP transfusion [mL, median (range)] | 175.7 (0-1200) | 139.5 (0-1200) | 266.6 (0-1200) | 0.003 |
Table 3 Specific risk factors for venous thromboembolism in the two groups n (%)
Variables | All patients (n = 229) | Group A (n = 157) | Group B (n = 72) | P value |
BMI > 30 kg/m2 | 36 (17.1) | 26 (17.8) | 10 (15.4) | 0.410 |
Diabetes | 47 (20.5) | 33 (21.0) | 14 (19.4) | 0.460 |
Cardiovascular disease | 56 (24.5) | 43 (27.0) | 13 (18.1) | 0.080 |
Table 4 Analysis of possible risk factors for venous thromboembolism
Variable | Exp (B) | 95% CI | P value |
Child-Pugh score (score A vs B) | 0.004 | 0.00-15.32 | 0.906 |
MELD score | 1.748 | 0.96-3.16 | 0.132 |
Type of resection (minor vs major) | 0.004 | 0.00-17.52 | 0.914 |
Platelet count | 0.990 | 0.99-1.00 | 0.776 |
Esophageal varices | 0.001 | 0.00-18.22 | 0.525 |
BMI | 0.001 | 0.00-11.45 | 0.687 |
Diabetes | 0.001 | 0.00-12.45 | 0.631 |
Cardiovascular disease | 0.001 | 0.00-19.31 | 0.570 |
Duration of surgery | 0.997 | 0.98-1.01 | 0.720 |
i.o. blood transfusion (mL) | 1.000 | 0.99-1.00 | 0.490 |
i.o. FFP transfusion (mL) | 1.001 | 0.99-1.00 | 0.518 |
VTE prophylaxis | 0.455 | 0.02-7.38 | 0.531 |
Table 5 Analysis of possible risk factors for hemorrhagic complications
Variable | Exp (B) | 95% CI | P value |
Child-Pugh score (score A vs B) | 0.004 | 0.00-23.72 | 0.742 |
MELD score | 1.280 | 0.83-1.95 | 0.252 |
Type of resection (minor vs major) | 0.004 | 0.00-20.75 | 0.763 |
Platelet count | 0.987 | 0.99-1.02 | 0.445 |
Esophageal varices | 5.559 | 0.99-31.14 | 0.050 |
BMI | 0.000 | 0.00-27.45 | 0.389 |
Diabetes | 0.000 | 0.00-24.28 | 0.248 |
Cardiovascular disease | 1.564 | 0.27-8.77 | 0.454 |
Duration of surgery | 0.997 | 0.98-1.00 | 0.460 |
i.o. blood transfusion (mL) | 1.001 | 0.99-1.00 | 0.315 |
i.o. FFP transfusion (mL) | 1.002 | 0.98-1.00 | 0.073 |
VTE prophylaxis | 0.443 | 0.26-20.42 | 0.387 |
- Citation: Vivarelli M, Zanello M, Zanfi C, Cucchetti A, Ravaioli M, Gaudio MD, Cescon M, Lauro A, Montanari E, Grazi GL, Pinna AD. Prophylaxis for venous thromboembolism after resection of hepatocellular carcinoma on cirrhosis: Is it necessary? World J Gastroenterol 2010; 16(17): 2146-2150
- URL: https://www.wjgnet.com/1007-9327/full/v16/i17/2146.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i17.2146