Effects of Haobie Yangyin Ruanjian Decoction on hepatic fibrosis induced by carbon tetrachloride in rats

doi:10.3748/wjg.v16.i12.1458

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 12

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4164)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-5) series.

Item

Count

PDF

451

HTML

3145

Figures (1-3)

311

Tables (1-5)

257

Sum=4164

Mar 28, 2010 (publication date) through Feb 18, 2025

Times Cited of This Article

Times Cited (13)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Mar 28, 2010; 16(12): 1458-1464
Published online Mar 28, 2010. doi: 10.3748/wjg.v16.i12.1458

Table 1 Effect of HYRD on serum levels of ALT, AST, TP and Alb (mean ± SD)

Groups	ALT (U/L)	AST (U/L)	TP (g/L)	Alb (g/L)
Control	20.94 ± 8.76^b	26.11 ± 11.81^b	76.9 ± 13.1^a	36.3 ± 5.2^b
Model	62.40 ± 25.59	99.93 ± 38.76	45.8 ± 14.8	24.3 ± 5.3
Low-dosage HYRD group	47.92 ± 19.65	70.72 ± 28.53^a	53.2 ± 23.5	28.0 ± 7.4
Medium-dosage HYRD group	44.36 ± 20.50^a	74.06 ± 25.14^a	58.8 ± 24.9	30.6 ± 7.5^a
High-dosage HYRD group	34.29 ± 11.42^b	49.95 ± 19.47^b	67.1 ± 20.2^a	33.0 ± 5.6^b

^aP < 0.05,

^bP < 0.01 vs model group. HYRD: Haobie Yangyin Ruanjian Decoction; ALT: Alanine transaminase; AST: Aspartate transaminase; TP: Total protein; Alb: Albumin.

Table 2 Effect of HYRD on hepatic hydroxyproline content (mean ± SD)

Groups	Hydroxyproline(mg/g dry weight)
Control	0.18 ± 0.13^b
Model	2.39 ± 0.28
Low-dosage HYRD group	1.89 ± 0.99
Medium-dosage HYRD group	1.29 ± 0.56^b
High-dosage HYRD group	1.22 ± 0.45^b

^bP < 0.01 vs model group.

Table 3 Effect of HYRD on serum levels of PCIII, HA, LN and CIV (mean ± SD)

Groups	PCIII (μg/mL)	HA (ng/mL)	LN (ng/mL)	CIV (ng/mL)
Control	15.16 ± 15.12^b	205.30 ± 48.92^a	82.02 ± 8.86	21.71 ± 1.76
Model	35.73 ± 17.90	563.82 ± 335.54	89.57 ± 7.59	29.20 ± 6.17
Low-dosage HYRD group	27.87 ± 10.13	464.19 ± 283.41	79.86 ± 9.52	26.38 ± 8.61
Medium-dosage HYRD group	24.72 ± 10.87^a	256.46 ± 95.98^b	86.34 ± 8.30	24.41 ± 4.46
High-dosage HYRD group	20.34 ± 13.92^b	161.51 ± 48.29^b	83.26 ± 13.20	26.22 ± 7.97

^aP < 0.05,

^bP < 0.01 vs model group. PCIII: Type III precollagen; HA: Hyaluronic acid; LN: Laminin; CIV: Type IV collagen.

Table 4 Liver histopathological semi-quantitative scores (mean ± SD)

Groups	n	Scores					Staging scores
Groups	n	0	I	II	III	IV	Staging scores
Control	6	6					0.00 ± 0.00^b
Model	13				2	11	26.08 ± 5.85
Low-dosage HYRD group	9				4	5	16.72 ± 6.05^b
Medium-dosage HYRD group	11		1	3	5	2	12.77 ± 6.21^b
High-dosage HYRD group	11	1	3	5	2		4.86 ± 2.66^b

^bP < 0.01 vs model group.

Table 5 Expression of TGF-β1 and Smad3 (mean ± SD)

Groups	TGF-β1/β-actin	Smad3/β-actin
Control	1.00 ± 0.00^b	0.62 ± 0.08^b
Model	3.29 ± 2.08	1.33 ± 0.10
Low-dosage HYRD group	2.52 ± 1.57	1.20 ± 0.07^b
Medium-dosage HYRD group	2.14 ± 1.42	1.16 ± 0.05^b
High-dosage HYRD group	1.68 ± 0.51^a	0.79 ± 0.06^b

^aP < 0.05,

^bP < 0.01 vs model group. TGF: Transforming growth factor.

Citation: Yang FR, Fang BW, Lou JS. Effects of Haobie Yangyin Ruanjian Decoction on hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol 2010; 16(12): 1458-1464
URL: https://www.wjgnet.com/1007-9327/full/v16/i12/1458.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i12.1458