Expression of thymidylate synthase and glutathione-s-transferase π in patients with esophageal squamous cell carcinoma

Table 1 Relationship between TS and clinicopathological characteristics of ESCC

Factor	n	(+)	(-)	Positive (%)	P value
Sex
M	86	40	46	46.51
F	16	3	13	18.75	0.039
Age (yr)
< 60	58	27	31	46.55
≥ 60	44	16	28	36.36	0.302
Histological grade
Well	32	7	25	21.88
Moderate & poor	70	36	34	51.43	0.005
Lymph node metastasis
(-)	55	24	31	43.64
(+)	47	19	28	40.43	0.743
Location1
Upper	11	4	7	36.36
Middle	55	22	33	40.00
Lower	36	17	19	47.22	0.822
T Stage
T0-1	7	4	3	57.14
T2-4	95	39	56	41.04	0.405

¹Location: Upper, upper intra-thoracic esophagus; Middle, middle intra-thoracic esophagus; Lower, lower intra-thoracic esophagus. TS: Thymidylate synthase; ESCC: Esophageal squamous cell carcinoma.

Table 2 Relationship between GST-π and clinicopathological characteristics of ESCC

Factor	n	(+)	(-)	Positive (%)	P value
Sex
M	86	46	40	53.49
F	16	9	7	56.25	0.839
Age (yr)
< 60	58	33	25	56.90
≥ 60	44	22	22	50.00	0.489
Histological grade
Well	32	21	11	65.63
Moderate	50	27	23	54.00
Poor	20	7	13	35.00	0.031
Lymph node metastasis
(-)	55	31	24	56.36
(+)	47	24	23	51.06	0.592
Location1
Upper	11	5	6	45.45
Middle	55	29	26	52.73
Lower	36	21	15	58.33	0.660
T Stage
T0-1	7	3	4	2.86
T2-4	95	52	43	54.74	0.543

¹Location: Upper, upper intra-thoracic esophagus; Middle, middle intra-thoracic esophagus; Lower, lower intra-thoracic esophagus. GST-π: Glutathione-s-transferase π.