Superiority of split dose midazolam as conscious sedation for outpatient colonoscopy

Table 1 Clinical characteristics of patients (mean ± SD)

	Group A (n = 40)	Group B (n = 40)	P value
Age (yr)	31.33 ± 9.76	31.23 ± 9.13	0.962
Gender (M/F)	34/6	36/4	0.737
Body mass index	23.80 ± 3.40	23.43 ± 3.78	0.642
No. of patients with previous colonoscopy (%)	11 (27.5%)	10 (25.0%)	0.779
Indication for colonoscopy n (%)
Change in bowel habit	9 (22.5)	10 (25.0)	0.527
Abdominal pain	10 (25.0)	12 (30.0)
Rectal bleeding	6 (15.0)	7 (17.5)
Polyp surveillance	13 (32.5)	9 (22.5)
Anemia	2 (5.0)	2 (5.0)
Time from onset of sedation to scope (min)	1.18 ± 0.50	0.89 ± 0.31	0.003
Total procedure time (min)	14.80 ± 3.80	14.61 ± 3.83	0.824
Time to ileal intubation (min)	7.49 ± 3.24	8.21 ± 3.37	0.328

Table 2 Safety of sedation with split dose midazolam and meperidine vs single dose midazolam and meperidine (mean ± SD)

	Group A (n = 40)	Group B (n = 40)	P value
Baseline systolic BP (mmHg)	125.20 ± 9.76	125.40 ± 10.15	0.929
Baseline pulse rate (/min)	71.90 ± 9.71	72.63 ± 8.99	0.730
Baseline oxygen saturation (%)	97.88 ± 1.98	97.95 ± 2.04	0.868
Drop in blood pressure	1 (2.5%)	2 (5.0%)	0.556
Alteration in heart rate	3 (7.5%)	2 (5.0%)	0.745
Drop in oxygen saturation	2 (5.0%)	8 (20.0%)	0.043

Table 3 Recovery rate from sedation state (mean ± SD)

	Group A (n = 40)	Group B (n = 40)	P value
Aldrete score (5 min)	4.28 ± 1.06	5.75 ± 0.95	< 0.001
Aldrete score (10 min)	6.55 ± 0.50	7.00 ± 0.68	0.001
Aldrete score (30 min)	8.73 ± 0.85	9.32 ± 0.69	0.001
Time from scope out to discharge	37.05 ± 6.87	33.75 ± 5.75	0.022

Table 4 Visual analog scale for pain, memory, and satisfaction reported by patients

	Group A (n = 40)	Group B (n = 40)	Pvalue
Pain	0.95 ± 1.15	1.58 ± 1.15	0.018
Memory
On insertion	0.80 ± 0.82	1.08 ± 0.89	0.155
On ileal intubation	1.38 ± 1.21	1.93 ± 0.94	0.026
On scope out	0.93 ± 1.02	1.58 ± 1.38	0.019
Satisfaction	8.93 ± 1.07	8.68 ± 1.09	0.305