Cardiopulmonary bypass induced microcirculatory injury of the small bowel in rats

Table 1 Macrohemodynamic parameters in CPB and sham animals (mean ± SD)

Variables	Groups	Prior to CPB	CPB 30 min	CPB 60 min	Post CPB 60 min	Post CPB 120 min
MAP (mmHg)	CPB	74 ± 8	77 ± 7	75 ± 6	75 ± 5	72 ± 5
	Sham	73 ± 5	75 ± 6	77 ± 6	75 ± 7	77 ± 5
pH	CPB	7.40 ± 0.02	7.36 ± 0.02ac	7.31 ± 0.04bc	7.27 ± 0.04bc	7.22 ± 0.03bc
	Sham	7.40 ± 0.02	7.39 ± 0.01	7.40 ± 0.02	7.39 ± 0.02	7.39 ± 0.02
PaO2 (mmHg)	CPB	414 ± 16	279 ± 13bc	280 ± 14bc	370 ± 21bc	372 ± 21bc
	Sham	404 ± 16	401 ± 16	394 ± 15	406 ± 14	402 ± 19
PaCO2 (mmHg)	CPB	38.8 ± 4.2	39.3 ± 2.8	38.9 ± 2.1	38.8 ± 3.8	40.2 ± 4.9
	Sham	39.1 ± 2.2	40.9 ± 1.6	38.3 ± 2.8	38.6 ± 2.5	40.3 ± 3.9
Hematocrit (%)	CPB	40.8 ± 2.2	33.0 ± 0.9bc	33.4 ± 1.0bc	32.3 ± 0.9bc	32.8 ± 0.8bc
	Sham	39.7 ± 1.4	40.8 ± 2.1	40.2 ± 1.7	39.3 ± 1.9	38.5 ± 1.6

^aP < 0.05,

^bP < 0.001 vs sham group;

^cP < 0.001 vs baseline.

Table 2 Changes in functional capillary density in CPB and sham animals (mean ± SD)

Variables	Groups	Prior to CPB	CPB 30 min	CPB 60 min	Post-CPB 60 min	Post-CPB 120 min
FCD in mucosa (cm-1)	CPB	511 ± 17	406 ± 12ab	328 ± 11ab	219 ± 13ab	150 ± 10ab
	Sham	504 ± 17	510 ± 20	499 ± 18	513 ± 14	507 ± 16
FCD in muscle (cm-1)	CPB	221 ± 13	152 ± 10ab	125 ± 9ab	102 ± 8ab	64 ± 7ab
	Sham	218 ± 14	221 ± 12	212 ± 17	217 ± 13	211 ± 14

^aP < 0.001 vs sham group;

^bP < 0.001 vs baseline.