Clinicopathological features of early gastric cancer with duodenal invasion

Table 1 Clinicopathological data for 41 cases of EGC with duodenal invasion

Authors	Year	Age (yr)	Gender	Location	Type	Size (mm)	Depth of invasion	Lymph node metastasis	Histological type	Distance of duodenalinvasion (mm)	Preoperativediagnosis
Ishii	1975	50	M	Circ	Depressed	32 × 25	m	-	Intestinal	7	ND
		47	M	Less	Elevated	30 × 15	sm	-	Intestinal	5	ND
Kuwayama[15]	1976	72	M	Ant-Less	Depressed	40 × 35	m	-	Diffuse	4	Impossible
Uchida[13]	1979	50	M	Circ	Depressed	32 × 25	m	-	Diffuse	7	ND
		61	M	ND	Mixed	35 × 21	sm	-	Intestinal	2	ND
		47	M	ND	Elevated	30 × 15	sm	-	Intestinal	5	ND
Kuwata[18]	1981	ND	ND	Less	Depressed	ND	sm	-	Diffuse	5	Impossible
		ND	ND	Gre	Elevated	ND	sm	-	Intestinal	6	Impossible
		ND	ND	Less	Elevated	ND	sm	-	Intestinal	2	Impossible
		ND	ND	Post	Mixed	ND	sm	-	Intestinal	1	Impossible
		ND	ND	Less	Mixed	30 × 15	sm	-	Intestinal	2	Impossible
		ND	ND	Less	Depressed	35 × 21	sm	-	Intestinal	1	Impossible
		67	M	Less	Mixed	30 × 15	sm	-	Intestinal	5	Impossible
Kato[17]	1993	63	F	Circ	Elevated	68 × 38	m	-	Intestinal	16	Possible
Nakazawa[9]	1994	58	M	Ant-Gre	Depressed	10 × 10	sm	-	Intestinal	3	Impossible
Boku[27]	1996	73	F	Circ	Elevated	70	sm	-	Intestinal	35	Possible
Ito[14]	1996	76	F	Less	Mixed	45 × 35	sm	-	Intestinal	25	Possible
Matsumoto[16]	2000	ND	ND	Less	Elevated	25 × 9	m	ND	Diffuse	3	Impossible
		61	M	Gre-Post	Elevated	25 × 10	sm	ND	Diffuse	10	Possible
		ND	ND	ND	Elevated	30 × 13	m	ND	Intestinal	3	Impossible
		ND	ND	ND	Elevated	65 × 23	m	ND	Intestinal	3	Impossible
		ND	ND	ND	Superficial	45 × 45	sm	ND	Intestinal	5	Impossible
Nogueira[12]	2000	ND	ND	ND	ND	ND	m	-	Diffuse	3	ND
		ND	ND	ND	ND	ND	sm	-	Intestinal	7	ND
Yasuda[23]	2000	59	F	Circ	Depressed	72 × 15	m	-	Diffuse	11	Impossible
Nakayama[37]	2001	59	F	Circ	Mixed	85 × 75	sm	-	Intestinal	38	Possible
Koufuji[29]	2003	77	M	Circ	Mixed	70 × 50	sm	-	Intestinal	2	ND
		65	M	Circ	Elevated	90 × 55	sm	-	Intestinal	2	ND
		66	F	Circ	Depressed	120 × 98	m	-	Diffuse	2	ND
		70	F	Circ	Depressed	130 × 102	m	-	Diffuse	8	ND
		58	M	Less	Depressed	55 × 24	sm	+	Diffuse	3	ND
		81	F	Gre	Depressed	30 × 20	sm	+	Intestinal	2	ND
		44	M	Less	Depressed	52 × 30	sm	-	Intestinal	5	ND
		57	F	Circ	Depressed	57 × 33	m	-	Diffuse	3	ND
		68	F	Gre	Depressed	40 × 38	sm	+	Diffuse	5	ND
		58	F	Circ	Depressed	80 × 65	sm	+	Diffuse	2	ND
Ishikawa[24]	2005	72	M	Less-Post	Elevated	68 × 37	m	-	Intestinal	20	Possible
Matsuda[6]	2007	79	F	Circ	Elevated	30 × 15	sm	-	Intestinal	12	Possible
Our case	2008	49	M	Less	Depressed	30 × 12	m	-	Intestinal	1	Impossible
		63	M	Less	Elevated	35 × 15	m	-	Intestinal	3	Impossible
		84	F	Circ	Elevated	85 × 80	m	-	Intestinal	38	Possible

F: Female; M: Male; ND: Not described; Circ: Circumferential; Less: Lesser curvature; Gre: Greater curvature; Ant: Anterior; Post: Posterior; Intestinal: Papillary and tubular adenocarcinomas; m: Mucosa; sm: Submucosa; Diffuse: Poorly differentiated adenocarcinoma, signet ring cell carcinoma, and mucinous adenocarcinoma.

Table 2 Clinicopathological characteristics of EGC with duodenal invasion

Characteristics	No. of patients	Length of duodenal invasion (mm)	P value
Age (yr)			0.276
< 60	13	7.2
> 60	16	11.7
Gender			0.029
Male	16	5.3
Female	13	15.2
Gross appearance			0.046
Depressed	16	4.3
Elevated	15	10.9
Tumor size (mm)			0.049
< 60	23	5.3
> 60	12	14.8
Depth of invasion			0.836
Mucosa	16	8.3
Submucosa	25	7.6
Histological type			0.088
Intestinal	28	9.1
Diffuse	13	5.1
Lymph node metastasis			0.006
Negative	32	8.9
Positive	4	3
Preoperative diagnosis of duodenal invasion			0.001
Possible	8	24.3
Impossible	16	3.6

Table 3 Clinicopathological characteristics of EGC with duodenal invasion for superficial spreading and small-sized types

Characteristics	Superficial spreading type	Small-sized type	Pvalue
Number of cases (%)	10 (27.0)	27 (73.0)
Age (yr)	68.7 ± 8.1	60.4 ± 11.2	0.031
Gender			0.048
Male	3	13
Female	7	6
Gross appearance			0.281
Depressed	3	12
Elevated	5	8
Depth of invasion			0.614
Mucosa	5	11
Submucosa	5	16
Histological type			0.847
Intestinal	7	18
Diffuse	3	9
Lymph node metastasis			0.773
Negative	9	19
Positive	1	3
Length of duodenal invasion (mm)	16.3	5.4	0.044
Preoperative diagnosis of duodenal invasion			0.003
Possible	5	3
Impossible	0	12