Development of a survival evaluation model for liver transplant recipients with hepatocellular carcinoma secondary to hepatitis B

Table 1 Demographic characteristics of recipients

Gender	n (%)
Male	129 (86.0)
Female	21 (14.0)
Median age (range)	51 (28-68)
Hepatitis B	150 (100)
Child’s score
A (5-6)	89 (59.3)
B (7-9)	46 (30.7)
C (10-15)	15 (10.0)
MELD score
≤ 18	132 (88.0)
> 18	18 (12.0)

Table 2 Pretransplant biochemical features of recipients

Variables	mean ± SD	Min value	Max value
Hb (g/dL)	12.23 ± 2.62	4.3	18.7
PLT (× 109)	131.4 ± 86.0	17	569
Urea (mmol/L)	4.90 ± 2.01	2.4	16.2
Crea (mg/dL)	1.06 ± 0.10	1	1.44
ALB (g/dL)	3.79 ± 0.68	2.01	5.28
TB (mg/dL)	26.8 ± 37.4	10	260.2
AKP (u/L)	160.51 ± 130.97	18	779
GGT (u/L)	215.34 ± 255.40	24	1630
AST (u/L)	89.83 ± 76.23	19	421
ALT (u/L)	101.49 ± 99.19	12	486
INR for PT	1.25 ± 0.24	1	2.16
AFP (&mgr;g/L)	426.65 ± 393.91	1.97	3000
Na+ ( mEq/L)	137.12 ± 5.33	114.2	150.3

Table 3 HCC-related features of recipients

Variable		Code	Frequency	Proportion (%)
History of	Present	1	15	10
hepatectomy	Absent	0	135	90
for HCC
Tumor diameter	1: < 5 cm	1	65	43.3
	2: 5 cm-	2	58	38.7
	Reference: > 10 cm	3	27	18
Tumor nodule	Nodule 1: one	1	93	62
	Nodule 2: two	2	31	20.7
	Reference: > two	3	26	17.3
Vascular invasion	Present	1	20	13.3
	Absent	0	130	86.7
Intrahepatic tumor	Present Absent	1	33	22
dissemination		0	117	78
Perihepatic	Present	1	10	6.7
lymphadenectasis	Absent	0	140	93.3

Table 4 Univariate Cox analysis of parameters

Variable	Regression coefficient	Regression coefficient SE	Wald	P-value	Expβ
Hb (loge)	-0.510	0.510	0.997	0.318	0.601
PLT (loge)	0.060	0.230	0.068	0.795	1.062
Urea (loge)	0.024	0.457	0.003	0.958	1.025
Crea (loge)	-0.427	1.671	0.065	0.798	0.652
ALB (loge)	-2.056	0.695	8.758	0.003	0.128
TB (loge)	0.277	0.165	2.838	0.092	1.320
AKP (loge)	0.581	0.214	7.328	0.007	1.787
GGT (loge)	0.254	0.148	2.930	0.087	1.289
AST (loge)	0.535	0.202	6.987	0.008	1.707
ALT (loge)	-0.172	0.178	0.926	0.336	0.842
INR (loge)	-0.065	0.818	0.006	0.937	0.937
AFP (loge)	0.104	0.071	2.742	0.098	1.109
Na+ (loge)	-7.161	3.144	5.190	0.023	0.001
History of hepatectomy	-0.160	0.474	0.115	0.735	0.852
Tumor diameter			6.245	0.089
1	-1.057	0.505	4.385	0.036	0.347
2	0.278	0.359	0.603	0.437	1.321
Tumor nodule			5.410	0.067
1	-0.391	0.364	1.153	0.283	0.677
2	0.419	0.419	1.000	0.317	1.520
Vascular invasion	0.368	0.300	1.503	0.22	1.445
Intrahepatic tumor dissemination	0.190	0.345	0.305	0.581	1.210
Perihepatic lymphadenectasis	0.583	0.526	1.226	0.268	1.791

Table 5 Multivariate Cox assessment of risk factors associated with post-LT mortality

Variable	Regression coefficient	Regression coefficient SE	Wald	P-value	Expβ
AKP (loge)	0.663	0.222	8.917	0.003	1.941
AFP (loge)	0.122	0.074	4.042	0.048	1.130
Na+ (loge)	-8.755	3.252	7.247	0.007	0.000
Tumor nodule			8.189	0.017	0.532
1	-0.631	0.373	4.265	0.041