Predictive value of Ki67 and p53 in locally advanced rectal cancer: Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy

Table 1 Tumor regression after neoadjuvant chemoradiotherapy[6]

	Histopathological tumor regression
	Primary tumor (downsizing)						Tumor stage (downstaging)
ypT	TRG0	TRG1	TRG2	TRG3	TRG4	ypUICC	TRG0	TRG1	TRG2	TRG3	TRG4
0	-	-	-	-	3	0	-	-	-	-	2
1	-	-	-	1	-	I	-	2	3	4	-
2	-	2	4	6	-	II	1	2	4	3	-
3	1	3	10	8	-	III	-	3	7	7	1
4	-	2	-	-	-	IV	-	-	-	1	-
Total	1	7	14	15	3	Total	1	7	14	15	3

Table 2 Correlations in pre-therapy tumor biopsies

Marker expression	Responders	Non-responders	P
TS < 1.201	10	1
TS ≥ 1.20	0	3	< 0.05
Ki67 < 40%	13	1
Ki67 ≥ 40%	3	5	< 0.05
p53 < 10%	6	3
p53 ≥ 10%	10	3	0.60

¹cut-off value.

Table 3 Correlations in post-therapy resection specimens

Marker expression	Responders	Non-responders	P
TS < 0.881	26	2	< 0.01
TS ≥ 0.88	4	4
Ki67 < 40%	22	1	< 0.01
Ki67 ≥ 40%	7	6
p53 < 10%	10	3	0.98
p53 ≥ 10%	19	4

¹cut-off value.