Ileal lesions in patients with ulcerative colitis after ileo-rectal anastomosis: Relationship with colonic metaplasia

Table 1 Demographic and clinical characteristics of patients with IRA for UC, CD, FAP and colon cancer

Patient	Sex	Age	Disease duration before surgery (yr)	Indication for surgery
UC
DLE	M	50	7	Refractory UC
LRA	F	25	7	CS-Refractory
DFML	F	49	2	CS-Refractory
ML	M	37	1	Refractory UC
BM	F	46	1	Toxic megacolon
TE	M	47	8	Refractory UC
SC	F	39	1	Refractory UC
CF	M	36	8	Toxic megacolon
LP	F	50	20	Refractory UC
NF	M	63	8	Refractory UC
TR	F	47	11	Toxic megacolon
CD
DAD	F	37	5	Colonic stenosis
MA	M	83	0	Colonic stenosis
CP	F	51	24	Pelvic abscess
DCE	M	30	5	Obstruction
DLLV	M	22	1	Refractory CD
CRL	F	59	1	Recto-vaginal fistula
FAP
ZG	F	57	16	FAP
Colon K
ML	F	68	1	Colon cancer

CS-Refractory: Steroid-refractory disease.

Table 2 Endoscopic and histologic findings at different time intervals in each patient with IRA for UC

Patient	Endo (n)	Ileal lesions at endoscopy	Histology
			Uninvolved ileum					Involved ileum
			Conventional histology[23]			Immunohistochemistry		Conventional histology[23]			Immunohistochemistry
			A	B	Colonic metaplasia	CG3 MoAb	Das-1 MoAb	A	B	Colonic metaplasia	CG3 MoAb	Das-1 MoAb
LRA	1	Y	1	0	N	-	-	ND	ND	ND	ND	ND
	2	Y	0	0	N	+	+	12	12	Y	+	+
	3	Y	2	0	N	+	+	6	1	N	+	+
	4	Y	0	0	N	+	+	6	0	N	+	+
	5	Y	0	0	N	+	+	8	0	N	+	+
DFML	1	Y	ND	ND	ND	ND	ND	0	0	N	+	-
	2	N	0	0	N	+	+	ND	ND	ND	ND	ND
SC	1	N	2	0	N	+	+	ND	ND	ND	ND	ND
ML	1	Y	0	0	N	+	+	10	4	Y	+	+
	2	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
TE	1	Y	ND	ND	ND	ND	ND	0	0	Y	+	-
LP	1	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
BM	1	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
	2	N	1	0	N	+	-	ND	ND	ND	ND	ND
	3	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
DLE	1	Y	0	0	N	+	-	6	2	Y	+	-
	2	Y	0	2	Y	+	+	0	2	Y	+	+
	3	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
CF	1	Y	ND	ND	ND	ND	ND	2	0	N	-	-
	2	Y	0	0	N	ND	ND	ND	ND	ND	ND	ND
NF	1	Y	ND	ND	ND	ND	ND	6	3	Y	ND	ND

Table 3 Endoscopical and histologic findings of patients with IRA for CD, FAP or colonic K

Patient	Endo (n)	Ileal lesions at endoscopy	Histology
			Uninvolved ileum					Involved ileum
			Conventional histology[23]			Immunohistochemistry		Conventional histology[23]			Immunohistochemistry
			Score	Score	Colonic	CG3	Das-1	Score	Score	Colonic	CG3	Das-1
			A	B	metaplasia	MoAb	MoAb	A	B	metaplasia	MoAb	MoAb
DAD	1	Y	ND	ND	ND	ND	ND	4	0	N	+	-
(CD-1)	2	Y	ND	ND	ND	ND	ND	0	0	N	+	-
	3	Y	0	0	N	+	-	0	0	N	+	-
	4	Y	0	0	N	+	-	8	4	Y	+	-
MA	1	N	4	4	Y	+	+	0	3	Y	+	+
(CD-2)
DCE	1	N	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
(CD-3)
CP	1	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
(CD-4)	2	N	2	0	N	ND	ND	ND	ND	ND	ND	ND
	3	Y	1	1	N	ND	ND	2	1	N	ND	ND
DLV	1	Y	ND	ND	ND	ND	ND	4	1	Y	+	+
(CD-5)	2	N	2	2	Y	ND	ND
	3	Y	4	2	Y	ND	ND	12	4	Y	ND	ND
CRL	1	Y	ND	ND	ND	ND	ND	10	3	Y	ND	ND
(CD-6)
ZG	1	N	0	0	N	ND	ND	8	2	N	ND	ND
(FAP)
ML	1	N	0	0	N	ND	ND	ND	ND	ND	ND	ND
(K)