A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis

Table 1 Mayo DAI indices

Stool frequency
0	Normal number of stools for this patient
1	1 to 2 more stools than normal
2	3 to 4 more stools than normal
3	5 or more stools than normal
Rectal bleeding
0	No blood seen
1	Streaks of blood with stool less than half the time
2	Obvious blood with stool most of the time
3	Blood alone passed
Findings of endoscope
0	Normal or inactive disease
1	Mild disease (erythema, decreased vascular pattern, mild friability)
2	Moderate disease (marked erythema, absent vascular pattern, friability, erosions)
3	Severe disease (spontaneous bleeding, ulceration)
Physician’s global assessment
0	Normal
1	Mild disease
2	Moderate disease
3	Severe disease

Table 2 Clinical characteristics of ulcerative colitis

		TG (n = 21)	CG (n = 21)
Age (yr)		38.8 ± 10.4	37.1 ± 8.01
Sex	Male (%)	16 (76.2)	15 (71.4)
	Female (%)	5 (23.8)	6 (28.6)
Location	Rectum (%)	8 (38.1)	9 (42.9)
	Rectosigmoid (%)	12 (57.1)	11 (52.4)
	Left colon (%)	1 (4.8)	1 (4.7)
Type	Chronic relapse (%)	13 (61.9)	12 (57.1)
	Chronic persistence (%)	8 (38.1)	9 (42.9)
Severity	Mild (%)	5 (23.8)	6 (28.6)
	Moderate (%)	16 (76.2)	15 (71.4)

Table 3 Mayo scores of TG and CG at initial and final points

Mayo scores	Initial point	Final point
TG (n = 21)a	5.87 (4.29-7.43)	1.86 (1.03-2.69)
CG (n = 21)	6.05 (4.97-7.13)	2.57 (1.92-3.22)

^aP < 0.05 vs CG.

Table 4 Histological grade of TG and CG

Grade	TG (n = 21)		CG (n = 21)
	Initial point	Final point	Initial point	Final point
Ia	4	12	5	8
IIc	10	6	12	11
IIIe	7	3	4	2
IV	0	0	0	0

^aP < 0.05, TG vs CG;

^cP < 0.05, TG vs CG;

^eP < 0.05, TG vs CG.

Table 5 Positive percentages of PPAR-γ and NF-κB in TG and CG

	TG (n = 21)		CG (n = 21)
	Initial point	Final point	Initial point	Final point
PPAR-γa (%)	26.2	47.76	24.9	39.24
	(22.98-29.49)	(43.42-50.09)	(21.49-28.32)	(35.81-42.67)
NF-κBc (%)	58.09	21.19	58	27
	(54.51-61.68)	(19.13-23.25)	(53.21-61.02)	(21.08-32.92)

^aP < 0.05, initial point to final point of TG vs CG;

^cP < 0.05, initial point to final point of TG vs CG.

Table 6 Histological grade and PPAR-γ and NF-κB expression

		Expression positivity (100%)
		I	II	III	IV
Initial points	n	4	10	7	0
	NF-κB	46.09-51.91	52.11-56.89	61.35-70.65	0
	PPAR-γ	31.57-39.93	24.54-29.06	16.30-20.55	0
Final points	n	12	6	3	0
	NF-κB	21.55-26.62	18.93-20.07	8.42-20.92	0
	PPAR-γ	37.20-44.97	49.82-56.51	55.50-69.84	0