Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma

Table 1 Characteristics of untreated esophageal SCC patients and controls (mean  ± SE)

Parameter	Patients	Controls	P
n	21	10
Age	56.7 ± 1.9	51.1 ± 3.5	0.118
Sex (Female/Male)	7/14	5/5	0.425
BMI	23.8 ± 1.4	25.1 ± 0.6	0.370
Cigarette usage (Yes/No)	10/11	3/7	0.242

BMI: body mass index.

Table 2 Correlation between mRNA expression and protein levels of CYP2E1, CYP3A4, CYP3A5, and CYP2C8 in normal esophageal tissue and SCC

Normal esophageal tissue	Spearmen R	P
CYP2E1	-0.09	0.72
CYP3A4	0.07	0.76
CYP3A5	0.19	0.41
CYP2C8	0.07	0.76
Esophageal SCC
CYP2E1	0.02	0.96
CYP3A4	0.16	0.65
CYP3A5	0.49	0.15
CYP2C8	-0.22	0.53