Yilmaz Y, Dolar E, Ulukaya E, Akgoz S, Keskin M, Kiyici M, Aker S, Yilmaztepe A, Gurel S, Gulten M, Nak SG. Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. World J Gastroenterol 2007; 13(6): 837-844 [PMID: 17352011 DOI: 10.3748/wjg.v13.i6.837]
Corresponding Author of This Article
Yusuf Yilmaz, MD, Uludag Universitesi Tip Fakultesi Ic Hastaliklari Gorukle, Bursa 16059, Turkey. yusufyilmaz@uludag.edu.tr
Article-Type of This Article
Viral Hepatitis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 6 Diagnostic performance of serum M30-antigen and M65-antigen levels in discriminating NAFLD patients with severe fibrosis from subjects with early fibrosis
Table 7 Diagnostic value of serum biomarkers in combination with CT scans for the diagnosis of definitive NASH according to multivariate regression analysis
P
Odds ratio
95% CI
Sensitivity(%)
Specificity(%)
Positive predictivevalue (%)
Negative predictivevalue (%)
Accuracy(%)
Combination
CT
0.001
0.891
0.831-0.955
86.10
83.30
86.10
83.30
84.80
M30-antigen
0.002
1.029
1.011-1.048
Combination
CT
0.003
0.916
0.865-0.971
83.30
83.30
85.70
86.60
83.30
M65-antigen
0.003
1.015
1.005-1.025
Citation: Yilmaz Y, Dolar E, Ulukaya E, Akgoz S, Keskin M, Kiyici M, Aker S, Yilmaztepe A, Gurel S, Gulten M, Nak SG. Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. World J Gastroenterol 2007; 13(6): 837-844