Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice

Table 1 Effect of As₂O₃ on Flt-1 and KDR/Flk-1 expression in tumor xenografts (fluorescence intensity) (n = 10, mean ± SD)

Group	Flt-1	KDR/Flk-1
Control	137.41 ± 3.36	141.62 ± 1.66
2.5 mg/kg	103.53 ± 2.23b	114.99 ± 2.19b
5 mg/kg	72.17 ± 0.87bd	101.11 ± 1.89bd

^bP < 0.001, treatment groups vs control group;

^dP < 0.001, 5 mg/kg group vs 2.5 mg group.

Table 2 Effect of As₂O₃ on VEGF-stimulated growth of tumor cells (%)

	As2O3 (ng/mL)
	2.5	5	10	15	20
VEGF165	105.79	106.62	100.97	107.59	109.38
VEGF165 + 2.5 μmol/L As2O3	84.24	97.95	97.59	100.48	94.94
VEGF165 + 5 μmol/L As2O3	76.87	68.55	83.74	85.06	84.94

Table 3 Effect of As₂O₃ on cell cycle of ECV304 cells (%)

Groups	G1	G2/G1	S	Apoptosis
Control	94.24	2.05	5.76	0
0.5 μmol/L As2O3	96.17	1.81	2.59	0
2.5 μmol/L As2O3	96.15	1.91	t0	14.84
5 μmol/L As2O3	96.96	1.84	0	18.90