Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors: A prospective controlled two-center study

Table 1 The sensitivity and specificity of results analysis

	Disease existent	Disease non-existent
Test positive	a	b	a + b
Test negative	c	d	c + d
	a + c	b + d

Table 2 Results based on contrast-enhanced CHI during the arterial phase

	Tumor present	Tumor not present
Test positive	40	19	59
Test negative	19	22	41
	59	41	100

Table 3 Results based on contrast-enhanced CHI during the portal-venous phase

	Tumor present	Tumor not present
Test positive	54	10	64
Test negative	5	31	36
	59	41	100

Table 4 Results based on contrast-enhanced CHI during the late phase

	Tumor present	Tumor not present
Test positive	58	4	62
Test negative	1	37	38
	59	41	100

Table 5 Diagnostic value of quantitative CHI for detection of malignant hepatic tumors in different phases after intravenous application of ultrasound contrast agent

	Arterial phase	Portal-venous phase	Late venous phase
Specificity (%)	53.7	75.6	90.2
Sensitivity (%)	67.8	91.5	98.3
Positive prognostic value	67.8	84.4	93.5
Negative prognostic value	53.7	86.1	97.4

Table 6 Specificity and sensitivity for both testing centers

	Center 1 n = 50	Center 2 n = 50	Total n = 100
Specificity (%)	85.7	95.0	90.2
Sensitivity (%)	100	96.7	98.3
Negative prognostic value	100	95.0	97.4
Positive prognostic value	90.6	96.7	93.5