Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease

doi:10.3748/wjg.v13.i34.4610

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Sep 14, 2007 (publication date) through Mar 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2007; 13(34): 4610-4614
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4610

Table 1 Demographic characteristics of patients enrolled in the study. Updated Sydney scores are given

Parameters	Pretreatment	Posttreatment	Chronicgastritis
N of patients	56		16
Age (mean ± SD)	60.13 ± 17.38		57.11 ± 15.81
Male/Female	46/10		8/8
Non smoking/smoking	16/40		6/10
Gastric ulcer	21	0	-
Duodenal ulcer	35	0	-
History of NSAID use	33/52		4/16
H pylori positive/negative	41/11^a	7/45^b	11/5
Patients with evidence of gastritis	49/52^a	34/52^d	13/16
(Total updated Sydney Score > 0)
Site of gastric inflammation
Antrum (no of patients)	28	21	8
Corpus (no of patients)	8	6	3
Disseminated (no of patients)	13	7	5
Total updated Sydney score (mean ± SD)	4.69 ± 1.93^a	2.69 ± 1.22^f	4.27 ± 0.65
Neutrophil infiltration score (mean ± SD)	1.77 ± 0.59^a	0.81 ± 0.32^f	1.73 ± 0.73
Monocyte infiltration score (mean ± SD)	2.15 ± 0.68^a	1.05 ± 0.61^f	1.73 ± 0.38
Lymphocyte infiltration score (mean ± SD)	0.87 ± 0.35^a	0.13 ± 0.08^c	0.69 ± 0.32
Mucosal atrophy score (mean ± SD)	0.55 ± 0.17^a	0.38 ± 0.11^e	0.58 ± 0.30
Intestinal metaplasia (mean ± SD)	0.29 ± 0.04^a	0.13 ± 0.08^e	0.19 ± 0.07
Density of H pylori (mean ± SD)	1.56 ± 0.28^a	0.33 ± 0.07^f	1.45 ± 0.39

^aP vs chronic gastritis, non significant; ^b,d,fP < 0.01,

^cP < 0.05, vs pre-treatment scores.

^eP vs pre-treatment scores; non significant.

Table 2 Concentrations of soluble triggering receptor expressed on myeloid cells-s (sTREM-1) and tumor necrosis factor-alpha (TNFα) of supernatants of tissue samples taken from patients with either duodenal or gastric ulcer disease or chronic gastritis at pre-treatment

Parameters	Duodenal ulcer		Gastric ulcer		Chronic Gastritis
Parameters	H pylori (+)	H pylori (-)	H pylori (+)	H pylori (-)	H pylori (+)	H pylori (-)
N	35	0	14	7	9	7
sTREM-1 [median (range), pg/g of tissue]
0	32.41 (13.32)	-	317.27 (73.98)^a	112.41 (38.71)	6.21 (0.81)^c	5.18 (0.77)
LPS	102.41 (40.43)	-	455.41 (98.53)^b	214.55 (44.81)	12.67 (2.16)^c	9.37 (1.55)
Gastric juice	17.91 (7.11)	-	150.14 (41.16)^c	118.48 (54.93)	10.07 (2.02)^c	7.42 (1.22)
TNFα [median (range), pg/g of tissue]
0	10.62 (2.07)	-	7.58 (1.75)^c	6.40 (1.52)	8.11 (1.31)^c	5.98 (1.45)
LPS	28.25 (3.35)	-	45.33 (13.06)^c	21.44 (8.12)	19.07 (4.72)^c	17.87 (2.11)
Gastric juice	18.02 (5.97)	-	10.76 (2.08)^c	8.51 (2.05)	10.17 (3.23)^c	9.13 (1.61)

Patients were divided as either H pylori-positive or H pylori-negative. LPS: Endotoxin of Escherichia coli O144:H4.

^aP < 0.05,

^bP < 0.01, vs H pylori negative patients.

^cP vs H pylori negative patients. non-significant.

Table 3 Influence of treatment on the secretion of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and tumor necrosis factor-alpha (TNFα) by the mucosa of H pylori-positive patients with gastric and duodenal ulcers

Parameters	H pylori-positive with gastric ulcer		H pylori-positive with duodenal ulcer
Parameters	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment
sTREM-1 [median (range), pg/g of tissue]
0	203.21 (88.91)	8.23 (5.79)^b	86.82 (35.41)	3.90 (2.84)^d
LPS	418.87 (127.56)	14.31 (7.11)^b	144.90 (58.79)	6.13 (4.07)^d
TNFα [median (range), pg/g of tissue]
0	12.67 (226.79)	9.51 (8.02)^a	12.47 (133.45)	10.31 (20.41)^a
LPS	31.07 (231.89)	20.12 (13.51)^a	34.05 (150.36)	17.88 (23.11)^a

^bP < 0.001,

^dP < 0.01, vs pre treatment;

^aP: non-significant, vs pre treatment.

Table 4 Correlations between sTREM-1 and TNFα and parameters of gastritis score in non and LPS stimulated supernatants of H pylori positive patients with duodenal and gastric ulcer and of patients with chronic gastritis

Parameters ofGastritis score	*Supernatants of mucosa sampled from H pylori-positive patients with duodenal ulcer diseasepre-treatment*
	Absence of LPS		Presence of LPS
	sTREM-1	TNFα	sTREM-1	TNFα
Neutrophils infiltration	P = NS	P = NS	P = NS	P = NS
Monocytes infiltration	P = NS	P < 0.01	P < 0.05	P < 0.01
	Supernatants of mucosa sampled from H pylori- positive patients with gastric ulcer disease pre-treatment
Neutrophils infiltration	P = NS	P < 0.05	P < 0.01	P < 0.05
Monocytes infiltration	P < 0.01	P < 0.01	P < 0.01	P < 0.01
	Supernatants of mucosa sampled from H pylori-positive patients with chronic gastritis
Neutrophils infiltration	P = NS	P < 0.05	P = NS	P < 0.05
Monocytes infiltration	P = NS	P < 0.05	P = NS	P < 0.01

Citation: Koussoulas V, Vassiliou S, Spyridaki E, Demonakou M, Vaki I, Barbatzas C, Giamarellou H, Giamarellos-Bourboulis EJ. Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease. World J Gastroenterol 2007; 13(34): 4610-4614
URL: https://www.wjgnet.com/1007-9327/full/v13/i34/4610.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i34.4610