Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease

doi:10.3748/wjg.v13.i34.4610

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 13, Issue 34

This Article

Reference Citation Analysis (0)

(0)

(3406)

(3)

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Rapid Communication

World J Gastroenterol. Sep 14, 2007; 13(34): 4610-4614
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4610

Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease

Evangelos J Giamarellos-Bourboulis, Helen Giamarellou, Charalambos Barbatzas, Ilia Vaki, Maria Demonakou, Ekaterini Spyridaki, Spyridon Vassiliou, Vassilios Koussoulas

Vassilios Koussoulas, Spyridon Vassiliou, Charalambos Barbatzas, Department of Gastroenterology, Sismanoglion General Hospital of Athens, University of Athens, Medical School, Greece

Ekaterini Spyridaki, Ilia Vaki, Helen Giamarellou, Evangelos J Giamarellos-Bourboulis, 4^th Department of Internal Medicine, University of Athens, Medical School, Greece

Maria Demonakou, Department of Pathology, Sismanoglion General Hospital of Athens, University of Athens, Medical School, Greece

Author contributions: All authors contributed equally to the work.

Correspondence to: Vassilios Koussoulas, MD, Sismanoglion General Hospital, 1 Sismanogliou Str., Athens 15126, Greece. kous73@yahoo.gr

Telephone: +30-210-8039798 Fax: +30-210-8024454

Received: February 21, 2007
Revised: March 13, 2007
Accepted: March 21, 2007
Published online: September 14, 2007

Abstract

AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer.

METHODS: Seventy two patients were enrolled; 35 with duodenal, 21 with gastric ulcer and 16 with chronic gastritis. Patients were endoscoped and gastric juice was aspirated. Patients with duodenal and gastric ulcer underwent a second endoscopy post-treatment. Biopsies were incubated in the absence/presence of endotoxins or gastric juice. Supernatants were collected and sTREM-1 and TNFα were measured by enzyme immunoabsorbent assays. Scoring of gastritis was performed before and after treatment according to updated Sydney score.

RESULTS: Patients with duodenal and gastric ulcer and those with chronic gastritis had similar scores of gastritis. sTREM-1 was higher in supernatants of tissue samples of H pylori-positive than of H pylori-negative patients with gastric ulcer. Median (± SE) sTREM-1 was found increased in supernatants of patients with gastric ulcer before treatment (203.21 ± 88.91 pg/1000 cells) compared to supernatants either from the same patients post-treatment (8.23 ± 5.79 pg/1000 cells) or from patients with chronic gastritis (6.21 ± 0.71 pg/1000 cells) (P < 0.001 and < 0.001, respectively). Similar differences for sTREM-1 were recorded among LPS-stimulated tissue samples of patients (P = 0.001). Similar differences were not found for TNFα. Positive correlations were found between sTREM-1 of supernatants from patients with both duodenal and gastric ulcer before treatment and the degree of infiltration of neutrophils and monocytes.

CONCLUSION: sTREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer. sTREM-1 was released at the presence of H pylori from the inflamed gastric mucosa in the field of gastric ulcer.

Keywords: sTREM-1; Chronic gastritis; Gastric ulcer; Duodenal ulcer

Koussoulas V, Vassiliou S, Spyridaki E, Demonakou M, Vaki I, Barbatzas C, Giamarellou H, Giamarellos-Bourboulis EJ. Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells (strem-1) in peptic ulcer disease. World J Gastroenterol 2007; 13(34): 4610-4614 [PMID: 17729416 DOI: 10.3748/wjg.v13.i34.4610]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.