Copyright
©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2007; 13(34): 4554-4559
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4554
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4554
Table 1 Expression of PTEN in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues
Parameters | Cases (n) | Positive cases | Mean score of PTEN staining (mean ± SD) | ||
Nucleus | Cytoplasm | Cell membrane | |||
HCC (Edmondson grading system) | 31 | 20ac | 0abc | 4.19 ± 3.31abc | 4.77 ± 3.92 |
GradeIandI-II | 10 | 8 | 0 | 5.80 ± 3.12e | 5.30 ± 3.68 |
Grade II | 7 | 4 | 0 | 4.14 ± 3.89 | 4.86 ± 4.56 |
Grade II-III and above | 14 | 8 | 0 | 3.07 ± 2.87e | 4.36 ± 4.01 |
Paracancerous tissue | 25 | 24 | 3.88 ± 3.14ab | 7.88 ± 0.93abd | 5.16 ± 3.69d |
Non-tumor liver tissue | 13 | 13 | 5.79 ± 2.31bc | 7.77 ± 0.93bcd | 3.92 ± 3.35d |
Cirrhotic liver tissue | 5 | 5 | 7.40 ± 1.14 | 8.40 ± 0.55 | 4.40 ± 4.10 |
Hepatitis tissue | 3 | 3 | 4.33 ± 3.79 | 8.00 ± 1.00 | 4.33 ± 3.79 |
Normal liver tissue | 5 | 5 | 5.0 ± 1.41 | 7.00 ± 0.71 | 3.20 ± 2.95 |
Intrahepatic vascular embolism | |||||
Present | 11 | 5 | 0b | 3.00 ± 3.46be | 3.27 ± 3.79 |
Absent | 14 | 12 | 0b | 6.28 ± 2.37be | 6.71 ± 2.89 |
Table 2 Expression of PPM1A in hepatocellular carcinomas, para-cancerous tissues and non-tumor liver tissues
Parameters | Cases (n) | Mean score of PPM1A staining (mean ± SD) | |
Nucleus | Cytoplasm | ||
HCC (Edmondson grades) | 31 | 3.45 ± 3.00abc | 6.32 ± 3.00abc |
GradeIandI-II | 10 | 5.60 ± 2.54e | 3.90 ± 4.14e |
Grade II | 7 | 3.57 ± 2.15b | 7.86 ± 0.69 |
Grade II-III and above | 14 | 1.86 ± 2.79d,b | 7.28 ± 1.38be |
Paracancerous tissue | 25 | 6.28 ± 1.95ab | 2.08 ± 3.45ab |
Non-tumor liver tissue | 13 | 5.38 ± 1.45be | 0cb |
Liver cirrhosis | 5 | 6.40 ± 0.55 | 0 |
Hepatitis | 3 | 3.33 ± 0.58 | 0 |
Normal liver tissue | 5 | 5.60 ± 1.14 | 0 |
Intrahepatic vascular embolism | |||
Present | 11 | 3.82 ± 3.22 | 6.09 ± 3.11 |
Absent | 14 | 3.71 ± 3.05 | 6.14 ± 3.44 |
Table 3 Expression of P-Smad2 in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues
Parameters | Cases (n) | Mean score of P-Smad2 staining (mean ± SD) | |
Nucleus | Cytoplasm | ||
HCC (Edmondson grades) | 31 | 8.61 ± 0.68bd | 1.74 ± 3.08abd |
GradeIandI-II | 10 | 8.70 ± 0.48 | 4.90 ± 3.54c |
Grade II | 7 | 7.85 ± 1.07 | 0.71 ± 1.89c |
Grade II-III and above | 14 | 8.79 ± 0.58 | 0d |
Paracancerous tissue | 25 | 8.28 ± 0.74b | 7.28 ± 1.21ab |
Non-tumor liver tissue | 13 | 7.08 ± 1.61bd | 5.31 ± 2.84bd |
Cirrhosis tissue | 5 | 8.40 ± 0.55c | 7.40 ± 1.81 |
Hepatitis tissue | 3 | 5.33 ± 0.58c | 1.33 ± 2.31 |
Normal liver tissue | 5 | 6.80 ± 1.64 | 5.60 ± 0.89 |
Intrahepatic vascular embolism | |||
Present | 11 | 8.82 ± 0.40 | 2.36 ± 3.35 |
Absent | 14 | 8.43 ± 0.76 | 2.00 ± 3.37 |
Table 4 Relationship of PTEN, PPM1A and P-Smad2 with HCC, paracancerous and non-tumor liver tissues
Types | Cases (n) | PTEN | PPM1A | P-Smad2 | |||
Cytoplasm | Nucleus | Cytoplasm | Nucleus | Cytoplasm | Nucleus | ||
HCC | 31 | 20 | 0 | 26 | 20 | 8 | 31 |
Paracancerous tissue | 25 | 24 | 17 | 7 | 25 | 25 | 25 |
Non-tumor liver tissue | 13 | 13 | 12 | 0 | 13 | 11 | 13 |
Table 5 Relationship of PPM1A and P-Smad2 with different Edmondson grades of HCC
Pathological type | Cases (n) | PPM1A | P-Smad2 | ||
Cytoplasm | Nucleus | Cytoplasm | Nucleus | ||
HCC (Edmondson grade) | 31 | 26 | 20 | 8 | 31 |
GradeIandI-II | 10 | 5 | 9 | 7 | 10 |
Grade II | 7 | 7 | 6 | 1 | 7 |
Grade II-III and above | 14 | 14 | 5 | 0 | 14 |
- Citation: Wu SK, Wang BJ, Yang Y, Feng XH, Zhao XP, Yang DL. Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues. World J Gastroenterol 2007; 13(34): 4554-4559
- URL: https://www.wjgnet.com/1007-9327/full/v13/i34/4554.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i34.4554