Liver Cancer
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2007; 13(34): 4554-4559
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4554
Table 1 Expression of PTEN in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues
ParametersCases (n)Positive cases Mean score of PTEN staining (mean ± SD)
NucleusCytoplasmCell membrane
HCC (Edmondson grading system)3120ac0abc4.19 ± 3.31abc4.77 ± 3.92
GradeIandI-II10805.80 ± 3.12e5.30 ± 3.68
Grade II7404.14 ± 3.894.86 ± 4.56
Grade II-III and above14803.07 ± 2.87e4.36 ± 4.01
Paracancerous tissue25243.88 ± 3.14ab7.88 ± 0.93abd5.16 ± 3.69d
Non-tumor liver tissue13135.79 ± 2.31bc7.77 ± 0.93bcd3.92 ± 3.35d
Cirrhotic liver tissue557.40 ± 1.148.40 ± 0.554.40 ± 4.10
Hepatitis tissue334.33 ± 3.798.00 ± 1.004.33 ± 3.79
Normal liver tissue555.0 ± 1.417.00 ± 0.713.20 ± 2.95
Intrahepatic vascular embolism
Present1150b3.00 ± 3.46be3.27 ± 3.79
Absent14120b6.28 ± 2.37be6.71 ± 2.89
Table 2 Expression of PPM1A in hepatocellular carcinomas, para-cancerous tissues and non-tumor liver tissues
ParametersCases (n) Mean score of PPM1A staining (mean ± SD)
NucleusCytoplasm
HCC (Edmondson grades)313.45 ± 3.00abc6.32 ± 3.00abc
GradeIandI-II105.60 ± 2.54e3.90 ± 4.14e
Grade II73.57 ± 2.15b7.86 ± 0.69
Grade II-III and above141.86 ± 2.79d,b7.28 ± 1.38be
Paracancerous tissue256.28 ± 1.95ab2.08 ± 3.45ab
Non-tumor liver tissue135.38 ± 1.45be0cb
Liver cirrhosis56.40 ± 0.550
Hepatitis33.33 ± 0.580
Normal liver tissue55.60 ± 1.140
Intrahepatic vascular embolism
Present113.82 ± 3.226.09 ± 3.11
Absent143.71 ± 3.056.14 ± 3.44
Table 3 Expression of P-Smad2 in hepatocellular carcinomas, paracancerous tissues and non-tumor liver tissues
ParametersCases (n) Mean score of P-Smad2 staining (mean ± SD)
NucleusCytoplasm
HCC (Edmondson grades)318.61 ± 0.68bd1.74 ± 3.08abd
GradeIandI-II108.70 ± 0.484.90 ± 3.54c
Grade II77.85 ± 1.070.71 ± 1.89c
Grade II-III and above148.79 ± 0.580d
Paracancerous tissue258.28 ± 0.74b7.28 ± 1.21ab
Non-tumor liver tissue137.08 ± 1.61bd5.31 ± 2.84bd
Cirrhosis tissue58.40 ± 0.55c7.40 ± 1.81
Hepatitis tissue35.33 ± 0.58c1.33 ± 2.31
Normal liver tissue56.80 ± 1.645.60 ± 0.89
Intrahepatic vascular embolism
Present118.82 ± 0.402.36 ± 3.35
Absent148.43 ± 0.762.00 ± 3.37
Table 4 Relationship of PTEN, PPM1A and P-Smad2 with HCC, paracancerous and non-tumor liver tissues
TypesCases (n)PTEN
PPM1A
P-Smad2
CytoplasmNucleusCytoplasmNucleusCytoplasmNucleus
HCC312002620831
Paracancerous tissue2524177252525
Non-tumor liver tissue1313120131113
Table 5 Relationship of PPM1A and P-Smad2 with different Edmondson grades of HCC
Pathological typeCases (n)PPM1A
P-Smad2
CytoplasmNucleusCytoplasmNucleus
HCC (Edmondson grade)312620831
GradeIandI-II1059710
Grade II77617
Grade II-III and above14145014