Rapid Communication
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2006; 12(43): 7019-7024
Published online Nov 21, 2006. doi: 10.3748/wjg.v12.i43.7019
Table 1 Biochemical, hematological and virological parameters of all enrolled patients distributed across the four groups
Parameter (mean value)Group 1(n = 17)Group 2(n = 22)Group 3(n = 19)Group 4(n = 12)P
ALT (U/L)41.88177.752960.001
AST (U/L)228055.31500.001
ALP (U/L)100111116.4238.80.001
INR1.31.11.41.20.003
Bilirubin (μmol/L)1013.840.4300.001
Albumin (g/L)4037.628.925.40.005
WBC (109/L)7.16.14.97.20.160
Hemoglobin (g/L)125129.6118.4620.740
Platelets (109/L)253202121.32130.230
HBV DNA level
< 200 copies/mL5231NS
200-105 copies/mL10888NS
> 105 copies/mL21283NS
Table 2 HBV genotype distribution across different stages of liver disease and in relation to HBeAg status in 70 patients
Study cohort (n)HBV genotype % (n)
DEACMixed
Group 1 (17)58.8 (10)-5.9 (1)-35.3 (6)
Group 2 (22)95.5 (21)--4.5 (1)-
Group 3 (19)84.2 (16)15.8 (3)---
Group 4 (12)83.3 (10)8.3 (1)--8.3 (1)
HBeAg + (18)88.9 (16)-5.6 (1)5.6 (1)-
HBeAg - (52)78.8 (41)7.7 (4)--13.5 (7)
Table 3 Hepatitis B virus genotype D patients’ biochemical, hematological and virological parameters distributed across the four groups (mean ± SD)
ParameterGroup 1(n = 10)Group 2(n = 21)Group 3(n = 16)Group 4(n = 10)P
Age (yr)45 ± 1835 ± 9.952.1 ± 7.761 ± 120.015
ALT (U/L)40.3 ± 8176.9 ± 100.754.1 ± 30.499.3 ± 79.90.001
AST (U/L)21.1 ± 6.578.6 ± 56.863.8 ± 48.5158.3 ± 167.60.001
ALP (U/L)98.6 ± 39.9112.6 ± 41143.8 ± 6.2239.9 ± 2010.001
Bilirubin (μmol/L)10.6 ± 4.914.1 ± 10.248.6 ± 60.427.8 ± 23.20.001
Albumin (g/L)41.5 ± 3.237.8 ± 4.627.8 ± 7.924.7 ± 8.40.007
WBC (109/L)7.5 ± 2.26.3 ± 1.76.12 ± 3.16.2 ± 1.90.100
Hemoglobin (g/L)127.7 ± 42.5129.2 ± 57.565.5 ± 55.962.5 ± 54.50.704
Platelets (109/ L)250 ± 84.3207.2 ± 56130.8 ± 56217.6 ± 97.40.113
HBeAg -/+5/512/915/19/10.024
Table 4 Predisposing factors for advanced hepatitis B virus genotype D liver disease
VariableCoefficient95% CIP
Age-0.01-0.02 to 0.0005< 0.001
Univariate analysisGender0.5 0.03 to 1.1< 0.001
AST0.20.09 to 0.3< 0.001
ALT0.040.01 to 0.03< 0.001
ALK0.01-0.001 to 0.02< 0.001
Albumin-0.2-0.3 to -0.9< 0.001
Bilirubin0.080.0009 to 0.1< 0.001
Multivariate analysisHemoglobin-0.05-0.08 to -0.030.001
Albumin-0.004 -0.007 to -0.0010.002