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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 7, 2006; 12(41): 6620-6626
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6620
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6620
Table 1 Demographic and virologic characteristics of basal core promoter 1762/1764 mutants
Characteristics | Mutant | Wild type | P |
Number | 124 | 156 | |
Age (yr) (mean ± SD) | 50.9 ± 13.5 | 46.3 ± 15.9 | 0.01 |
Male/Female | 93/31 | 112/44 | 0.5 |
Asian/Non-Asian | 107/17 | 121/35 | 0.06 |
Genotype, n (%) | < 0.0001 | ||
A | 12/121 (9.9) | 28/147 (19.1) | |
B | 18/121 (14.9) | 54/147 (36.7) | |
C | 90/121 (74.4) | 62/147 (42.2) | |
Baseline HBV-DNA level (mean ± SD, copies/mL) | 6.7 ± 1.6 Log10 | 7.3 ± 1.9 Log10 | 0.003 |
PC1 1896 mutant, n (%) | 0.8 | ||
Yes | 35/124 (28.2) | 46/156 (29.5) | |
No | 89/124 (71.8) | 110/156 (70.5) | |
HBeAg, n (%) | 0.07 | ||
+ | 68/124 (54.8) | 101/154 (65.6) | |
− | 56/124 (45.2) | 53/154 (34.4) |
Table 2 Demographic and virologic characteristics of precore 1896 mutants
Characteristic | Mutant | Wild type | P |
Number | 112 | 270 | |
Age (yr) (mean ± SD) | 49.7 ± 14.8 | 47.3 ± 15.1 | 0.16 |
Male/Female | 77/35 | 192/78 | 0.6 |
Asian/Non-Asian | 99/13 | 201/69 | 0.002 |
Genotype, n (%) | < 0.0001 | ||
A | 2/93 (2.1) | 54/227 (23.8) | |
B | 53/93 (56.9) | 39/227 (17.2) | |
C | 38/93 (40.9) | 128/227 (56.4) | |
Baseline HBV-DNA level (mean ± SD, copies/mL) | 5.5 ± 2.0 Log10 | 6.5 ± 2.3 Log10 | < 0.0001 |
HBeAg, n (%) | < 0.0001 | ||
+ | 33/109 (30.1) | 161/268 (60.1) | |
− | 76/109 (69.7) | 107/268 (39.9) |
Table 3 Demographic and virologic characteristics of HBV genotypes
Characteristics | Genotype A | Genotype B | Genotype C | P |
n | 56 | 92 | 166 | |
Age (yr) (mean ± SD) | 51.0 ± 15.8 | 46.3 ± 17.7 | 47.4 ± 14.7 | 0.2 |
Male/Female | 47/9 | 64/28 | 117/49 | 0.02 |
Asian/Non-Asian | 16/40 | 84/8 | 157/9 | < 0.0001 |
HBV-DNA (mean ± SD, copies/mL) | 6.68 ± 2.53 Log10 | 6.12 ± 2.08 Log10 | 6.94 ± 1.81 Log10L | 0.003 |
HBeAg, n (%) | 0.0002 | |||
+ | 37/55 (67.3) | 35/91 (38.5) | 104/165 (63.0) | |
- | 18/55 (32.7) | 56/91 (61.5) | 61/165 (37.0) |
Table 4 Demographic and virologic characteristics of baseline serum HBV-DNA Levels (mean ± SD, copies/mL)
Characteristics | Mean HBV-DNA levels | P |
Sex | 0.0007 | |
Male | 6.39 ± 2.30 Log10 | |
Female | 5.52 ± 2.14 Log10 | |
Race | 0.24 | |
Asian | 6.05 ± 2.21 Log10 | |
Non-Asian | 6.39 ± 2.57 Log10 | |
HBeAg | < 0.0001 | |
+ (n = 194) | 7.42 ± 1.97 Log10 | |
− (n = 191) | 4.86 ± 1.81 Log10 |
Table 5 Univariate analysis of factors associated with non-HCC related liver deaths
Factor | Alive | Expired | P |
n | 326 | 43 | - |
Age (yr) (mean ± SD) | 45.5 ± 14.7 | 57.2 ± 12.2 | < 0.0001 |
Male/Female | 213/113 | 41/2 | < 0.0001 |
Asian/Non-Asian | 264/62 | 24/19 | 0.0005 |
Cirrhosis | < 0.0001 | ||
Yes | 77/139 | 38/139 | |
No1 | 257/261 | 4/261 | |
Baseline HBV-DNA level (mean ± SD) | 6.0 ± 2.38 Log10 copies/mL | 6.92 ± 1.96 Log10 copies/mL | 0.02 |
BCP 1762/1764 mutant | 0.07 | ||
Yes | 86 | 20 | |
No | 132 | 16 | |
PC 1896 mutant | 0.78 | ||
Yes | 86 | 12 | |
No | 223 | 30 | |
Genotype | 0.43 | ||
A | 46 | 8 | |
B | 76 | 8 | |
C | 126 | 19 | |
HBeAg | 0.17 | ||
+ | 159 | 26 | |
− | 163 | 17 |
Table 6 Univariate analysis of factors associated with development of HCC
Factor | HCC | No HCC | P |
n | 31 | 369 | |
Age (yr) (mean ± SD) | 57.4 ± 2.7 | 46.9 ± 0.8 | 0.0002 |
Male/Female | 28/3 | 254/115 | 0.006 |
Asian/Non-Asian | 26/5 | 288/81 | 0.4 |
Cirrhosis | < 0.0001 | ||
Yes | 22/139 | 117/139 | |
No | 9/261 | 252/261 | |
BCP 1762/1764 mutant | 0.007 | ||
Yes | 18 | 106 | |
No | 6 | 148 | |
PC 1896 mutant | 0.05 | ||
Yes | 14 | 98 | |
No | 17 | 253 | |
Genotype | 0.2 | ||
A | 2 | 54 | |
B | 8 | 84 | |
C | 19 | 147 | |
HBeAg | 0.3 | ||
+ | 12 | 165 | |
- | 18 | 180 | |
Baseline HBV-DNA level (mean ± SD, copies/mL) | 6.3 ± 1.4 Log10 | 6.1 ± 2.3 Log10 | 0.6 |
- Citation: Tong MJ, Blatt LM, Kao JH, Cheng JT, Corey WG. Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma. World J Gastroenterol 2006; 12(41): 6620-6626
- URL: https://www.wjgnet.com/1007-9327/full/v12/i41/6620.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i41.6620