A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer

Table 1 Demographic characteristics of patients with stomach cancer (n = 292)

	n
Median age	56 (22 -88)
Gender
Male	171
Female	121
Type of stomach cancer
Early cancer (EGC)	103
Advanced cancer (AGC)	189
Codon 72 polymorphism
Arg/Arg	101
Arg/Pro	126
Pro/Pro	65
Laurence classification
Intestinal type	140
Diffuse type	152
Differentiation
Well/Moderate	114
Poor	132
Signet ring cell	46

Table 2 Frequency of the codon 72 genotype

	n	Arg/Arg (%)	Arg/Pro (%)	Pro/Pro (%)
Control	216	89/216 (41.2)	103/216 (47.7)	24/216 (11.1)
Stomach cancer	292	101/292 (34.5)	126/292 (43.1)	65/292 (22.3)a1
AGC	189	75/189 (39.7)d	76/189 (39.9)	38/189 (20.4)b
EGC	103	26/103 (25.8)	50/103 (48.1)	27/103 (26.1)c2

^aP = 0.032, control vs stomach cance;

^bP = 0.029, control vs AGC;

^cP = 0.027, control vs EGC;

^dP = 0.038, AGC vs EGC;

¹OR = 3.9 (95% CI, 1.3-15.4, P = 0.039);

²OR = 5.25 (95% CI, 1.8-19.6, P = 0.021); OR: Odd ratio; CI: Confidence interval.

Table 3 Distribution of p53 genotypes and histopathological classification among the patients with gastric cancer

Histopathological classification (n)	p53 genotypes
	Arg/Arg	Arg/Pro	Pro/Pro
Control (216)	89/216(41.2)	103/216(47.7)	24/216(11.1)
Differentiation
Well to poorly (246)	88/292 (30.1)	151/292 (51.7)	53/292 (18.2)
Signet ring cell (46)	17/46 (37.0)	11/46 (23.0)	18/46 (39.1)ab
Tumor histologic type
Intestinal type (140)	48/140 (34.2)	60/140 (42.8)	31/140 (22.1)
Diffuse type (152)	53/152 (34.8)	66/152 (43.4)	34/152 (22.4)

^aP = 0.031, Well to poorly differentiation vs Signet ring cell;

^bP = 0.019, Control vs Signet ring cell.