Mutations of the AAAS gene in an Indian family with Allgrove's syndrome

Table 1 Summary of clinical features and laboratory investigation in both siblings with Allgrove’s syndrome

Variable	Elder sibling	Younger sibling
Dysphagia	Present	Present
Generalized pigmentation	Present	Present
Abdominal pain	Absent	Present
Decreased lacrimation	Present	Present
Postural hypotension	Absent	Absent
Palmoplantar keratosis	Absent	Present
Temporal optical pallor	Present	Present
Hemoglobin (mg%)	6.8	8.1
Albumin (mg%)	4.2	4.2
Pre-Synacthen cortisol (μg/deciliter)	3.94	3.37
Post-Synacthen cortisol (μg/deciliter)	5.16	4.1
Barium swallow	Aperistaltic dilated esophagus	Aperistaltic dilated esophagus
LES pressure on manometry (mmHg)	45	60