Published online Aug 7, 2006. doi: 10.3748/wjg.v12.i29.4767
Revised: February 8, 2006
Accepted: February 28, 2006
Published online: August 7, 2006
- Citation: Gibot S. TREM-1 expression during major abdominal surgery: Comment on the Gonzalez-Roldan et al paper. World J Gastroenterol 2006; 12(29): 4767-4767
- URL: https://www.wjgnet.com/1007-9327/full/v12/i29/4767.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i29.4767
I read with a great interest the paper by Gonzalez-Roldan et al[1]. The authors reported on the pattern expression of TREM-1 during sepsis and major abdominal surgery as compared to healthy controls and concluded that TREM-1 expression increased on the surface of monocytes after surgery. Several points deserve consideration. First, no data related to TREM-1 expression on neutrophils is provided. Second, of the 7 surgical patients, only 4 had both pre- and post-surgery cytometry analysis. Among these 4 patients, 2 displayed a decrease of TREM-1 expression after surgery. Therefore, it seems quite hazardous, based on these data, to conclude that TREM-1 increases after major uncomplicated surgery, reflecting a systemic inflammatory response.
The other question that arose from this study is related to the determination of the TREM-1 splice variant (svTREM-1). First, it is still unknown whether this variant is translated or not[2]. Anyway, the soluble form of TREM-1 is not believed to be related to this variant[3]. The authors observed an increase of the svTREM-1 mRNA after surgery or during sepsis. By using the described primers, one could also expect to see a PCR product corresponding to the natural form of TREM-1[3]. Unfortunately, such a product is not reported. Finally, it is rather disappointing not to see any measurement of plasma sTREM-1 in these patients in order to better characterise the “inflammatory” patients and the septic ones[4].
S- Editor Wang J E- Editor Bi L
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2. | Gingras MC, Lapillonne H, Margolin JF. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol Immunol. 2002;38:817-824. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 100] [Cited by in F6Publishing: 107] [Article Influence: 4.9] [Reference Citation Analysis (0)] |
3. | Gibot S, Kolopp-Sarda MN, Béné MC, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med. 2004;200:1419-1426. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 265] [Cited by in F6Publishing: 289] [Article Influence: 14.5] [Reference Citation Analysis (0)] |
4. | Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004;350:451-458. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 411] [Cited by in F6Publishing: 405] [Article Influence: 20.3] [Reference Citation Analysis (0)] |