Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology

Table 1 Demographics of patients and characteristics of adenomas

Patients	n		118
	Sex	Male/Female	71 (60%)/47 (40%)
	Age (yr)	Mean (range), Median	63 (25-86), 65
Adenomas	Size (mm)	Mean (range), Median	14 (3-55), 6
	Location	Left/Right	83 (70%)/35 (30%)
	Histology	Tubular/Tubulo-villous/Villous	82 (70%)/32 (27%)/4 (3%)
	Dysplasia	Low/High-grade	103 (87%)/15 (13%)
	Appearance	Pedunculated/Sessile	31 (26%)/87 (74%)

Table 2 Comparison of characteristics of adenomas with APC

Parameter		APC+	APC-	P
Size (SD)		13.5 (± 14.2)	13.8 (±15.5)	0.3641
Histology	Tubular	62 (76%)	20 (24%)	0.3272
	Tubulovillous	24 (75%)	8 (25%)
	Villous	4 (100%)	0 (0%)
Dysplasia	Low-grade	78 (76%)	25 (24%)	0.4943
	High-grade	12 (80%)	3 (20%)
Advancement	Advanced	36 (78%)	10 (22%)	0.4143
	Non-advanced	54 (75%)	18 (25%)
Location	Left	66 (80%)	17 (20%)	0.1573
	Right	24 (69%)	11 (31%)
Appearance	Sessile	66 (76%)	21 (24%)	0.5713
	Pedunculated	24(77%)	7 (23%)
Age (yr)	< 41	5 (63%)	3 (37%)	0.4382
	41-50	7 (64%)	4 (36%)
	51-60	27 (84%)	5 (16%)
	> 60	51 (76%)	16 (24%)

¹ Mann-Whitney test;

²χ² (Chi-square) test;

³ Fisher‘s exact test.