Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD

Table 1 Medication at time of harvest of biopsy specimens

	Medication	No of patients (%)
UC	Prednisone	12/37	32
	AZA	11/37	30
	ASA	8/37	22
	Ciclosporine	4/37	11
	No medication	12/37	32
	Any immunomodulating drug	20/37	54
CD	Prednisone	6/24	25
	AZA	5/24	21
	ASA	2/24	8
	Ciproxin	1/24	4
	Anti-TNF	2/24	8
	No medication	13/24	54
	Any immunomodulating drug	10/24	42

Table 2 RT-PCR and ASCA results in relation to medication

	Medication	RT-PCR +	(%)	RT-PCR -	(%)	ASCA +	(%)	ASCA -	(%)
UC	Prednisone	6/7	86	6/30	20	5/12	42	7/25	28
	AZA	1/7	14	10/30	33	2/12	17	9/25	36
	ASA	3/7	43	5/30	17	0		8/25	32
	Ciclosporine	1/7	14	3/30	10	1/12	8	3/25	12
	No medication	0		12/30	40	7/12	58	6/25	24
CD	Prednisone	2/7	29	4/17	24	4/16	25	2/8	25
	AZA	2/7	29	3/17	18	2/16	13	3/8	38
	ASA	1/7	14	1/17	6	1/16	6	1/8	13
	Ciproxin	1/7	14	0		1/16	6	0
	Anti-TNF	2/7	29	0		2/16	13	0
	No medication	2/7	29	11/17	65	8/16	50	5/8	63

Table 3 ASCA and RT-PCR detection of S. cerevisiae in CD patients

	ASCA positive	ASCA negative	Total
RT-PCR positive	4	3	7
RT-PCR negative	12	5	17
Total	16	8	24

Table 4 ASCA and RT-PCR detection of S. cerevisiae in UC patients

	ASCA positive	ASCA negative	Total
RT-PCR positive	4	3	7
RT-PCR negative	8	22	30
Total	12	25	37