Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues

Table 1 Summary of subcellular staining of KL - 6 mucin in colorectal adenocarcinoma

Group1	KL-6 mucin staining			n
	Apical membrane	Circumferential membrane	Cytoplasm
N	Negative	Negative	Negative	6
A	Positive	Negative	Negative	29
C	Positive	Negative	Positive	8
C	Negative	Positive	Negative	2
C	Negative	Positive	Positive	37

¹Patient groups N, A, and C were categorized according to the subcellular expression profile of KL - 6 mucin (see text).

Table 2 Relationship between clinicopathological factors and sbcellular staining profile of KL - 6 mucin in colorectal adenocarcinoma n(%)

Factors	n	Subcellular staining profile of KL - 6 mucin			P
		No staining	Apical membrane	Circumferential membrane and/or cytoplasm
Age(yr)					0.449
≤60	29	2(6.9)	12(41.4)	15 (51.7)
≥60	53	4(7.5)	17(32.1)	32 (60.4)
Sex					0.469
Male	55	4(7.3)	21(38.2)	30 (54.5)
Female	27	2(7.4)	8(29.6)	17 (63.0)
Differentiation					0.055
Well	50	6(12.0)	21(42.0)	23 (46.0)
Moderate	29	0(0)	8(27.6)	21 (72.4)
Poor	3	0(0)	0(0)	3 (100)
Venous invasion					0.0003
(+)	40	0(0)	9(22.5)	31 (77.5)
(-)	42	6(14.3)	20(47.6)	16 (38.1)
Lymphatic invasion6					<0.0001
(+)	24	0(0)	2(8.3)	22 (91.7)
(-)	58	6(10.3)	27(46.6)	25 (43.1)
D1epth of in0vasion					0.009
m	3	3(100)	0(0)	0 (0)
sm,mp	14	2(14.3)	4(28.6)	4 (28.6)
ss,se	59	1(1.7)	38(64.4)	38 (64.4)
Si	6	0(0)	5(83.3)	5 (83.3)
Histological stage					<0.0001
0	3	3(100)	0(0)	0 (0)
I	12	2(16.7)	2(16.7)	2 (16.7)
II	29	1(3.4)	8(27.6)	8 (27.6)
IIIa	29	0(0)	28(96.6)	28 (96.6)
IIIb	6	0(0)	6(100)	6 (100)
IV	3	0(0)	3(100)	3 (100)
Lymph node metastasis					<0.0001
(+)	36	0(0)	36(100)	36 (100)
(-)	46	6(13.0)	11(24.0)	11 (24.0)
Liver metastasis
(+)	7	0(0)	7(100)	7 (100)
(-)	75	6(8.0)	40(53.3)	40 (53.3)	0.058