Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells

Table 1 Effect of TZD on apoptosis in pancreatic tumor cells. Extent of apoptosis following treatment of pancreatic cancer cell lines with 20 μmol/L of TZD (RGZ or PGZ) for three days was measured by the incorporation of FITC-dUTP in the presence of TdT enzyme to detect DNA fragmentation as described in Methods. Cells were stained with RNase A/PI and analyzed by flow cytometry. The mean±SD of five independent experiments each performed in triplicate are shown.

Treatment	Apoptosis (%)
	Panc-1	Capan-2	HPAC	P3-HPAC
Control (DMSO)	1.16±0.15	0.88±014	0.46±0.19	0.66±017
RGZ	1.20±0.17	0.90±0.22	0.38±0.17	0.58±0.19
PGZ	1.19±0.14	0.93±0.17	0.40±0.18	0.57±0.13