Asthma and gastroesophageal reflux disease: Effect of long-term pantoprazole therapy

Table 1 Demographic data of 34 asthmatic patients with or without GERD symptoms

	Symptomatic	Asymptomatic
		GERD	Non-GERD
Number	16	11	7
Male/female	6/10	5/6	4/3
ERD	7	0	0
NERD	9	11	7
Age (mean±SD) (yrs)	33.75±10	38.27±5.68	36.14±8.76
DIS (mean±SD) (µm)	2.105±0.262	2.08±0.24	0.5±0.08
FEV1 (mean±SD) (L)	1.87±0.05	1.95±0.04	1.88±0.02

Table 2 Comparison of background characteristics of asthmatic patients with GERD and controls

	GERD(27)	Controls(7)	t-Test
Age (yrs) (mean±SD)	35.59±8.67	36.14±8.76	NS
Male/female	11/16	4/3	NS
QUEST score	8.8±4.5	0.12±0.8	P<0.0001
Erosive esophagitis	7 (4B, 2C, 1D)	0	P<0.05
DIS (mean±SD) (µm)	2.09±0.24	0.5±0.08	P<0.001
FEV1 (L)	1.91±0.045	1.88±0.02	NS

Table 3 Effect of treatment on dilation of intercellular space (DIS) in 25 responders to pantoprazole (mean±SD)

		Value (μm)	t-Test
	Baseline	2.105±0.261
Symptomatic			P<0.001
	After therapy	0.592±0.194
	Baseline	2.081±0.242
Asymptomatic			P<0.001
	After therapy	0.517±0.072

Table 4 Effect of therapy on asthma symptom score in GERD patients (mean±SD)

		Baseline	After therapy	t-test
	GERD	4.37±0.97	0.33±0.83	P<0.001
Patients
	Controls	4.57±0.79	4.14±0.38	P = NS