Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2005; 11(48): 7657-7660
Published online Dec 28, 2005. doi: 10.3748/wjg.v11.i48.7657
Published online Dec 28, 2005. doi: 10.3748/wjg.v11.i48.7657
Table 1 Demographic data of 34 asthmatic patients with or without GERD symptoms
Symptomatic | Asymptomatic | ||
GERD | Non-GERD | ||
Number | 16 | 11 | 7 |
Male/female | 6/10 | 5/6 | 4/3 |
ERD | 7 | 0 | 0 |
NERD | 9 | 11 | 7 |
Age (mean±SD) (yrs) | 33.75±10 | 38.27±5.68 | 36.14±8.76 |
DIS (mean±SD) (µm) | 2.105±0.262 | 2.08±0.24 | 0.5±0.08 |
FEV1 (mean±SD) (L) | 1.87±0.05 | 1.95±0.04 | 1.88±0.02 |
Table 2 Comparison of background characteristics of asthmatic patients with GERD and controls
GERD(27) | Controls(7) | t-Test | |
Age (yrs) (mean±SD) | 35.59±8.67 | 36.14±8.76 | NS |
Male/female | 11/16 | 4/3 | NS |
QUEST score | 8.8±4.5 | 0.12±0.8 | P<0.0001 |
Erosive esophagitis | 7 (4B, 2C, 1D) | 0 | P<0.05 |
DIS (mean±SD) (µm) | 2.09±0.24 | 0.5±0.08 | P<0.001 |
FEV1 (L) | 1.91±0.045 | 1.88±0.02 | NS |
Table 3 Effect of treatment on dilation of intercellular space (DIS) in 25 responders to pantoprazole (mean±SD)
Value (μm) | t-Test | ||
Baseline | 2.105±0.261 | ||
Symptomatic | P<0.001 | ||
After therapy | 0.592±0.194 | ||
Baseline | 2.081±0.242 | ||
Asymptomatic | P<0.001 | ||
After therapy | 0.517±0.072 |
Table 4 Effect of therapy on asthma symptom score in GERD patients (mean±SD)
Baseline | After therapy | t-test | ||
GERD | 4.37±0.97 | 0.33±0.83 | P<0.001 | |
Patients | ||||
Controls | 4.57±0.79 | 4.14±0.38 | P = NS |
- Citation: Carlo C, Anna F, Alessandra A, Carlo S, Desiree Z, Giulio DF. Asthma and gastroesophageal reflux disease: Effect of long-term pantoprazole therapy. World J Gastroenterol 2005; 11(48): 7657-7660
- URL: https://www.wjgnet.com/1007-9327/full/v11/i48/7657.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i48.7657