Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population

Table 1 Distribution of EBER-1-positive gastric carcinomas by anatomic site¹ and gender

	Total		Males		Females
	(EBER-1+/total) %		(EBER-1+/total) %		(EBER-1+/total) %
Total	24/330	7.3	13/173	7.5	11/157	7.0
Upper	3/44	6.8	3/31	9.7	0/13	0
Middle	13/128	10.2	7/67	10.4	6/61	9.8
Lower	8/156	5.1	3/74	4.1	5/82	6.1

¹In two cases, anatomic location could not be determined. All (one male and one female) were EBER-1-negative.

Table 2 Distribution of EBER-1-positive gastric carcinomas by histologic type and gender

	Total		Males		Females
	(EBER-1+/total) %		(EBER-1+/total) %		(EBER-1+/total) %
I-type	4/141	2.8	3.5	3/87	1/54	1.9
Tub1	0/42	0	0/28	0	0/14	0
Tub2	4/80	5.0	3/47	6.4	1/33	3.0
Muc	0/19	0	0/12	0	0/7	0
D-type	20/189	10.6	10/86	11.6	10/103	9.7
Por1	8/64	12.5	3/31	9.7	5/33	15.2
Por2	2/45	4.4	2/19	10.5	0/26	0
Sig	1/71	1.4	1/32	3.1	0/39	0
LEL	9/9	100	4/4	100	5/5	100

I-type: Intestinal-type adenocarcinoma; D-type: Diffuse-type adenocarcinoma.

Table 3 Comparison of demographic and pathologic variables between EBER-1-positive and EBER-1-negative gastric carcinomas¹

	EBER-1+/total	OR	95%CI	P
Gender				0.859
Female	11/157	1	Reference
Male	13/173	0.9	0.4-2.2
Age (yr)				0.013
20-49	0/87	<0.1
50-69	14/170	0.6	0.2-1.3
70-88	10/73	1	Reference
Decade				0.787
1980-1989	11/130	1	Reference
1990-2000	13/200	0.9	0.4-2.1
Tumor site				0.229
Cardia	3/35	1.9	0.5-7.5
Middle	13/137	2.2	0.9-5.5
Antrum	8/156	1	Reference
Lauren classification				0.005
Intestinal	4/141	1	Reference
Diffuse	20/189	4.9	1.6-14.8
Depth				0.273
Early	2/14	2.4	0.5-11.8
Advanced	22/316	1	Reference

¹Odds ratios and 95% confidence intervals were obtained from logistic analysis. Age was adjusted in the analysis of variables other than age.