Expression of cell cycle regulator p57kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: An immunohistochemical study

doi:10.3748/wjg.v11.i32.5057

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Aug 28, 2005 (publication date) through Nov 17, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2005; 11(32): 5057-5060
Published online Aug 28, 2005. doi: 10.3748/wjg.v11.i32.5057

Table 1 Expression of p57^kip2 protein in pancreatic cancer tissues

	p57^kip2 protein expression
Characteristics	-	+	++	+++	Rate (%)
Tumor tissue	17	11	3	1	46.9^a
Well-differentiated	7	9	2	1	63.2^c
Moderately or
poorly-differentiated	10	2	1	0	23.1^c
Lymph node metastasis	9	2	1	0	25.0^e
Non-lymph node
metastasis	8	9	2	1	60.0^e
Adjacent tissue	8	13	6	5	75.0^a

^aP<0.05,

^cP<0.05,

^eP>0.05 vs others.

Full Size Table

Table 2 Expression of cyclinE protein in pancreatic cancer tissues

Characteristics	CyclinE protein expression
Characteristics	-	+	++	+++	Rate (%)
Tumor tissue	10	7	9	6	68.8^a
Well-differentiated	9	5	4	1	52.6^c
Moderately or
poorly-differentiated	1	1	6	5	84.6^c
Lymph node metastasis	1	1	5	5	91.7^e
Non-lymph node
metastasis	9	6	4	1	55.0^e
Adjacent tissue	18	6	8	0	43.8^a

^aP<0.05,

^cP<0.05,

^eP<0.05 vs others.

Full Size Table

Table 3 Expression of PCNA in pancreatic cancer tissues

Characteristics	PCNA protein expression
Characteristics	-	+	Rate (%)
Tumor tissue	9	23	71.9^a
Well-differentiated	8	11	57.9^c
Moderately or poorly-differentiated	1	12	92.3^c
Lymph node metastasis	0	12	100^e
Non-lymph node metastasis	9	11	55.0^e
Adjacent tissue	18	14	43.8^a

^aP<0.05,

^cP<0.05,

^eP<0.05 vs others.

Full Size Table

Table 4 Relationship between expression of p57^kip2 and cyclinE proteins

p57^kip2	CyclinE protein expression
p57^kip2	-	+	++	+++	Rate (%)
–	4	4	6	3	76.5
+	4	3	2	2
++	2	0	0	1	60.0
+++	0	0	1	0

Full Size Table

Citation: Yue H, Jiang HY. Expression of cell cycle regulator p57^kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: An immunohistochemical study. World J Gastroenterol 2005; 11(32): 5057-5060
URL: https://www.wjgnet.com/1007-9327/full/v11/i32/5057.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i32.5057