Expression of cell cycle regulator p57kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: An immunohistochemical study

doi:10.3748/wjg.v11.i32.5057

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Aug 28, 2005 (publication date) through Nov 11, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2005; 11(32): 5057-5060
Published online Aug 28, 2005. doi: 10.3748/wjg.v11.i32.5057

Expression of cell cycle regulator p57^kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: An immunohistochemical study

Hui Yue, Hui-Yong Jiang

Hui Yue, Institute for Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China

Hui-Yong Jiang, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Hui Yue, Institute for Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. yh12070430@vip.sina.com

Telephone: +86-20-61641545 Fax: +86-20-61363220

Received: November 2, 2004
Revised: December 17, 2004
Accepted: December 21, 2004
Published online: August 28, 2005

Abstract

AIM: To investigate the effects of p57^kip2, cyclinE protein and proliferating cell nuclear antigen (PCNA) on occurrence and progression of human pancreatic cancer.

METHODS: The expression of p57^kip2, cyclinE protein and PCNA in tumor tissues and adjacent tissues from 32 patients with pancreatic cancer was detected by SP immunohistochemical technique.

RESULTS: The positive expression rate of p57^kip2 protein in tumor tissues was 46.9%, which was lower than that in adjacent pancreatic tissues (χ² = 5.317, P<0.05). p57^kip2 protein positive expression remarkably correlated with tumor cell differentiation (P<0.05), but not with lymph node metastasis (P>0.05). The positive expression rate of cyclinE protein in tumor tissues was 68.8%, which was higher than that in adjacent pancreatic tissues (χ² = 4.063, P<0.05). CyclinE protein positive expression significantly correlated with tumor cell differentiation and lymph node metastasis (P<0.05). The positive expression rate of PCNA in the tumor tissues was 71.9%, which was higher than that in adjacent pancreatic tissues (χ² = 5.189, P<0.05). PCNA positive expression remarkably correlated with tumor cell differentiation and lymph node metastasis (P<0.05).

CONCLUSION: The decreased expression of p57^kip2 and/or overexpression of cyclinE protein and PCNA may contribute to the occurrence and progression of pancreatic cancer. p57^kip2, cyclinE protein, and PCNA play an important role in occurrence and progression of pancreatic cancer.

Keywords: p57^kip2; CyclinE; PCNA; Human pancreatic cancer