Zhang DL, Zheng HM, Yu BJ, Jiang ZW, Li JS. Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock. World J Gastroenterol 2005; 11(28): 4409-4413 [PMID: 16038043 DOI: 10.3748/wjg.v11.i28.4409]
Corresponding Author of This Article
Dian-Liang Zhang, Department of General Surgery, Affiliated Hospital, Qingdao University Medial College, Qingdao 266003, Shandong Province, China. phdzdl@yahoo.com
Article-Type of This Article
Brief Reports
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World J Gastroenterol. Jul 28, 2005; 11(28): 4409-4413 Published online Jul 28, 2005. doi: 10.3748/wjg.v11.i28.4409
Table 1 Comparison of allele frequency between MAP group and SAP group
MAP (n = 106)
SAP (n = 109)
P
CC
94
95
IL-1β
CT
12
14
+3 594
TT
0
0
T allele
12 (5.7)
14 (6.4)
0.74
GG
0
0
IL-10
AA
75
81
-1 082
GA
31
28
G allele
31 (14.6)
28 (12.8)
0.592
CC
62
66
CD-14
TT
14
14
-159
CT
30
29
T allele
58 (27.4)
57 (26.1)
0.777
Table 2 Comparison of allele frequency between AP and controls
AP (n = 215)
Controls (n = 116)
P
CC
189
98
IL-1β
CT
26
18
+3 594
TT
0
0
T allele
26 (6.0)
18 (7.8)
0.399
GG
0
0
IL-10
AA
156
79
-1 082
GA
59
37
G allele
59 (13.7)
37 (15.9)
0.437
CC
128
71
CD-14
TT
28
13
-159
CT
59
32
T allele
115 (26.7)
58 (25.0)
0.626
Table 3 Comparison of allele frequency between septic shock and nonseptic shock groups
Septic shock (n = 33)
Nonseptic shock (n = 76)
P
CC
27
68
IL-1β
CT
6
8
+3 594
TT
0
0
T allele
6 (9.1)
8 (5.3)
0.289
GG
0
0
IL-10
AA
19
62
-1 082
GA
14
14
G allele
14 (21.2)
14 (9.2)
0.015
CC
19
47
CD-14
TT
5
9
-159
CT
9
20
T allele
19 (28.8)
38 (25.0)
0.559
Table 4 Comparison of allele frequency based on different etiologies of SAP (n)%
Allele
Alcoholic SAP (n = 23)
Gallstone SAP (n = 49)
Idiopathic SAP (n = 34)
P
IL-1β+3 594 T
3 (6.5)
6 (6.1)
5 (7.4)
0.952
IL-10-1 082 G
7 (15.2)
12 (12.2)
9 (13.2)
0.886
CD-14-159 T
11 (23.9)
25 (25.5)
21 (30.9)
0.653
Citation: Zhang DL, Zheng HM, Yu BJ, Jiang ZW, Li JS. Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock. World J Gastroenterol 2005; 11(28): 4409-4413