Oral Xeloda plus bi-platinu two-way combined chemotherapy in treatment of advanced gastrointestinal malignancies

doi:10.3748/wjg.v11.i28.4300

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jul 28, 2005; 11(28): 4300-4304
Published online Jul 28, 2005. doi: 10.3748/wjg.v11.i28.4300

Table 1 Clinical characteristics of stage IV gastrointestinal cancer

linical characteristics	Gastric cancer		Colorectal cancer
linical characteristics	X group	C group	X group	C group
ale/female	21/11	17/12	19/16	23/12
ge: mean (range/yr)	63.6 (3683)	61.0 (3380)	62.9 (4575)	60.8 (3474)
ecurrence (%)	14 (43.8)	14 (48.3)	8 (22.9)	9 (25.7)
etastasis
iver (%)	17 (53.1)	16 (55.2)	21 (60.0)	22 (62.9)
ung (%)	8 (25.0)	7 (24.1)	11 (31.4)	10 (28.6)
eliac lymph node (%)	21 (65.6)	21 (72.4)	14 (40.0)	15 (42.9)
thers (%)	8 (25.0)	9 (31.0)	12 (34.3)	10 (28.6)
revious chemotherapy	23 (71.9)	22 (75.9)	17 (48.6)	19 (54.3)

Table 2 Different chemotherapeutic effect of gastrointestinal cancers

Therapeutic effect	Gastric cancer		Colorectal cancer		Total
Therapeutic effect	X group	C group	X group	C group	X group	C group
n	24	25	31	34	55	59
CR (n)	1	1	1	0	2	1
PR (n)	13	10	14	14	27	24
NC (n)	5	10	12	14	17	24
PD (n)	5	4	4	6	9	10
CR+PR (n)	14	11	17	14	29	25
(%)	58.3	44.0	54.8	41.2	52.7	42.4
TTP (mo)	7.0±1.3^a	5.4±0.9	7.8±1.9^a	6.7±2.0	7.4±1.7^a	6.0±1.5
1-yr survival (%)	41.7a	36.0	64.5a	52.9	53.1a	44.5

^aP<0.05 vs C group.

Table 3 Chemotherapeutic side effects of gastrointestinal cancers (n)

Side effects	X group (n = 55)				C group (n = 59)
Side effects	I	II	III	IV	I	II	III	IV
Leukopenia	21	8	5	0	20	8	4	0
Thrombocytopenia	10	5	1	0	13	4	2	0
Nausea	15	19	10	2	16	20	11	2
Vomiting	11	11	4	1	14	12	3	2
Diarrhea	7	9	3	0	5	6	2	0
HFS	32	2	1	0	8	2	0	0
Neurotoxicity	12	11	0	0	14	12	1	0

Table 4 Chemotherapeutic DI of gastrointestinal cancers, mg/(m²×wk)

DI	X group			C group
DI	Oxal¹	DDP¹	Xeloda	Oxal¹	DDP¹	CF	5-FU
Standard	43.3	40.0	9 333.3	43.3	40.0	333.3	1 000.0
Actual	40.7	38.3	8 662.7	41.3	38.7	322.7	966.7
Relative	0.94	0.96	0.93	0.95	0.97	0.97	0.97

¹Oxal oxaliplatin; DDP cisplatin.

Table 5 The average cost per patient of two groups (mean±SD, ￥, US $)

Group	Hospitalization(d)	Cost of drug		Other cost		Total cost
Group	Hospitalization(d)	￥	US $	￥	US $	￥	US $
X	5.94±3.11a	7887.33±140.92a	950.28±16.98a	1250.02±101.43a	150.60±12.22a	9137.35±121.18	1100.89±14.60
C	9.37±2.73	6108.97±205.44	736.02±24.75	2 852.75±217.73	343.70±26.23	8961.72±211.59	1 079.73±25.50

^aP<0.05 vs C group.

Table 6 Comparison of cost-effectiveness of two groups

Group	Costs/efficient		Costs/TTP		Costs/1-year survival
Group	￥	US $	￥	US $	￥	US $
X	161.44±2.14^a	19.45±0.26^a	1243.18±16.49^a	149.78±1.99^a	172.24±2.28^a	20.75±0.27^a
C	210.37±4.97	25.35±0.60 1	506.17±35.56	181.47±4.28	201.61±4.76	24.29±0.57

^aP<0.05 vs C group.

Citation: Fan L, Liu WC, Zhang YJ, Ren J, Pan BR, Liu DH, Chen Y, Yu ZC. Oral Xeloda plus bi-platinu two-way combined chemotherapy in treatment of advanced gastrointestinal malignancies. World J Gastroenterol 2005; 11(28): 4300-4304
URL: https://www.wjgnet.com/1007-9327/full/v11/i28/4300.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i28.4300