Genetic polymorphisms of N-acetyltransferase 2 and colorectal cancer risk

Table 1 Frequency of NAT2 alleles in Hebei Han Chinese population

Alleles	Healthy controls		Patients
	Number	Frequency	Number		Frequency
WT	231	0.4874	80		0.4819
M1	24	0.0506	9		0.0542
M2	74	0.15611b		49		0.2952
M3	145	0.30592d		28		0.1687
M4	0	0	0		0
SUM	474	1	166		1

¹χ²=15.31,

^bP < 0.0001 and

²χ² = 25.33,

^dP < 0.0001 vs patients.

Table 2 Distribution frequencies of NAT2 genotype in Hebei Han Chinese population

		Rapid-acetylator genotype					Slow-acetylator genotype
		WT/WT	WT/M1	WT/M2	WT/M3	Sum	M1/M1	M1/M2	M1/M3	M2/M2	M2/M3	M3/M3	Sum
Controls	n	62	9	29	69	169	1	4	9	5	31	18	68
	%	26.2	3.8	12.2	29.1	71.3	0.4	1.7	3.8	2.1	13.1	7.6	28.7
Patients	n	15	1	35	14	65	1	2	4	3	6	2	18
	%	18.1	1.2	42.2	16.9	78.3	1.2	2.4	4.8	3.6	7.2	2.4	21.7
χ2		2.2	0.64	34.4	3.8	1.54	0	0	0.007	0.12	2.06	2.01	1.54
P		0.14	0.42	< 0.0001	0.03	0.22	1	1	0.94	0.73	0.15	0.16	0.22

Table 3 Relationship between NAT2 genotype and colorectal canceriation

Genotypes	Control		Patients		OR (95%CI)
	n	%	n	%
WT/WT	62	26.2	15	18.1	1
WT/M2	29	12.2	35	42.2	4.99 (2.27 - 9.38)
WT/M1	9	3.8	1	1.2	0.46 (0.05 - 3.92)
WT/M3	69	29.1	14	16.9	0.84 (0.38 - 1.88)
WT/WT and WT/Mx	169	71.3	65	78.3	1.59 (0.85 - 2.99)
Mx/Mx	68	28.7	18	21.7	1.09 (0.51 - 2.35)

x = 1, 2, 3, 4, OR: odds ratio; CI: confidence internal.

Table 4 Frequencies of genotype WT/M2 and M2/M3 in peripheral blood cells and cancer tissues of colorectal cancer patients

	WT/M2		M2/M3		Others
	n	%	n	%	n	%
Blood cells	23	42.6	5	9.3	26	48.2
Cancer tissues	12	22.21	13	24.12	29	53.7

¹χ² = 5.11, P = 0.020 and ²χ² = 4.27, P = 0.039 vs blood cells.