One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer

Table 1 Demographic characteristics and diagnosis of the 120 study patients.

	1-wk therapy	2-wk therapy
n	62	58
Mean age (range) yr	48±14 (19-72)	50±14 (18-78)
Male gender	36 (58)	30 (52)
Smokers (%)	16 (26)	13 (22)
Duodenal ulcer (n/%)	32 (52)	31 (53)
Gastric ulcer (%)	25 (40)	19 (33)
Duodenal and gastric ulcers (%)	5 (8)	8 (14)
Active ulcers (%)	24 (39)	19 (33)

Table 2 Eradication rates and 95% confidence intervals in the two treatment groups.

	Eradication rate	95%CI (%)
Intention to treat
1-wk group (%)	45/62 (73)	62-84
2-wk group (%)	44/58 (76)	65-87
Per protocol
1-wk group (%)	45/56 (80)	70-91
2-wk group (%)	44/53 (83)	73-93

Table 3 Demographic data and diagnosis in patients with eradicated or non-eradicated H pylori infection.

	Eradicated infection n = 89	Non- eradicated n = 20
Male gender (%)	44 (49)	12 (60)
Age (yr)	49±14	52±16
Smoking (%)	24 (27)	3 (15)
Duodenal ulcer (%)	46 (52)	10 (50)
Gastric ulcer (%)	34 (38)	7 (35)
Duodenal and gastric ulcers (%)	9 (10)	3 (15)

Table 4 Data from the control endoscopy.

	1-wk	2-wk
Active duodenal ulcer healed (%)	11/11 (100)	7/8 (87.5)
Active gastric ulcer healed (%)	10/11 (91)	10/11 (91)
Esophagitis (%)	5 (8.9)	4 (7.5)