Peroxynitrite induced decrease in Na+, K+-ATPase activity is restored by taurine

Table 1 Effect of taurine on liver plasma membrane Na⁺, K⁺-ATPase activity (values are mean±SD, n = 10).

Groups	Na+, K+-ATPase activity (nmol Pi/mg Pr/min)
Control	815.64±116.4
Taurine (1 mmol/L)	798.60±31.52
Taurine (2 mmol/L)	806.20±61.39
Taurine (5 mmol/L)	781.06±77.62

Table 2 Effects of 200 μmol/L decomposed ONOO^- and ONOO^- with and without taurine on liver plasma membrane Na⁺, K⁺-ATPase activity (values are mean±SD, n = 10).

Groups	Na+,K+-ATPase activity (nmol Pi/mg Pr/min)
Decomposed ONOO- (200 mmol/L)	261.86±38.32a
Decomposed ONOO- (200 mmol/L) +taurine (1 mmol/L)	460.24±51.28a
Decomposed ONOO- (200 mmol/L) +taurine (2 mmol/L)	452.07±50.92a
Decomposed ONOO- (200 mmol/L) +taurine (5 mmol/L)	435.61±71.44a
ONOO- (200 mmol/L)	62.36±18.77a
ONOO- (200 mmol/L)+taurine (1 mmol/L)	115.37±27.19a
ONOO- (200 mmol/L)+taurine (2 mmol/L)	114.34±27.34a
ONOO- (200 mmol/L)+taurine (5 mmol/L)	113.86±16.32a

Values not sharing a common superscript letter are significantly different by ANOVA (THS test),

^aP<0.05 vs others.

Table 3 Effects of taurine, 200 μmol/L decomposed ONOO^- and ONOO^- with and without taurine on liver plasma membrane. TBARS levels (values are mean±SD, n = 10).

Groups	TBARS (nmol MDA/mg Pr)
Control	4.84±0.45a
Taurine (1 mmol/L)	4.80±0.43a
Taurine (2 mmol/L)	4.73±0.39a
Taurine (5 mmol/L)	4.31±0.41a
Decomposed ONOO- 200 mmol/L	6.10±0.80a
ONOO- (200 mmol/L)	25.62±1.08a
ONOO- (200 mmol/L)+taurine (1 mmol/L)	19.80±0.78a
ONOO- (200 mmol/L)+taurine (2 mmol/L)	17.52±0.73a
ONOO- (200 mmol/L)+taurine (5 mmol/L)	14.80±0.85a

Values not sharing a common superscript letter are significantly different by ANOVA (THS test),

^aP<0.05 vs others.