Viral Hepatitis
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 14, 2005; 11(22): 3351-3356
Published online Jun 14, 2005. doi: 10.3748/wjg.v11.i22.3351
Table 1 Up-regulated genes by HCV core.
Accession numbersProteinCy5/Cy3
NM_005657Tumor protein p53 binding protein 1, TP53BP12.004
D50683TGF-betaIIR alpha2.072
NM_006595Apoptosis inhibitor 5, API52.199
NM_000612Insulin-like growth factor 2, IGF22.232
NM_002530Neurotrophic tyrosine kinase, receptor2.233
NM_000760Colony stimulating factor 3 receptor, CSF3R2.253
NM_014350TNF-induced protein, GG2-12.358
NM_006290Tumor necrosis factor, alpha-induced protein 3, TNFAIP32.359
NM_003151Signal transducer and activator of transcription 4, STAT42.390
U07139Voltage-gated calcium channel beta subunit2.423
NM_000014Alpha-2-macroglobulin, A2M2.526
NM_012112Chromosome 20 open reading frame 1, C20orf12.689
NM_002736Protein kinase, cAMP- dependent, regulatory2.710
NM_014575Schwannomin interacting protein 1, SCHIP12.737
U47077DNA-dependent protein kinase catalytic subunit, DNA-PKcs2.787
AF352051Proliferation potential-related protein2.827
NM_003998Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105, NF-kB13.005
NM_004728DEAD/H box polypeptide 213.149
NM_005100A kinase anchor protein 12, AKAP123.897
NM_005171Activating transcription factor 1, ATF14.142
BC008959Histocompatibility 134.760
NM_014863B cell RAG associated protein, BRAG5.769
NM_002291Laminin, beta 1, LAMB110.334
Table 2 Down-regulated genes by HCV core.
Accession numbersProteinCy5/Cy3
NM_000535PMS2 postmeiotic segregation increased 20.122
NM_012096Adaptor protein containing pH domain, PTB domain and leucine zipper motif, APPL0.386
NM_003844Tumor necrosis factor receptor superfamily, member 10a0.388
NM_001226Caspase 6, apoptosis-related cysteine protease0.400
NM_001229Caspase 9, apoptosis-related cysteine protease0.429
NM_002287Leukocyte-associated Ig-like receptor 10.440
AF090693Apoptosis-related RNA binding protein0.462
NM_021020Leucine zipper, putative tumor suppressor 1 LZTS10.464
NM_000062Serine or cysteine proteinase inhibitor0.471
NM_000575Interleukin 1, alpha0.472
AF016266TRAIL receptor 20.477
NM_003796RNA polymerase II subunit 5 RPB5-mediating protein, RMP0.485
NM_000629Interferon alpha, beta and omega receptor 1,IFNAR10.494
Table 3 Up-regulated genes by HCTP4 protein.
Accession numbersProteinCy5/Cy3
NM_002599Phosphodiesterase 2A, cGMP-stimulated (PDE2A)2.011
NM_053274FKBP-associated protein (FAP48), transcript variant 12.014
NM_012319LIV-1 protein, estrogen regulated (LIV-1)2.017
NM_007047Butyrophilin,subfamily 3, member A2 (BTN3A2)2.030
NM_021950Membrane-spanning 4-domains, subfamily A, member 1 (MS4A1)2.033
NM_000817Glutamate decarboxylase 1 (GAD1)2.048
NM_033625Ribosomal protein L34 (RPL34)2.055
NM_006526Zinc finger protein 217 (ZNF217)2.058
NM_112219Esterase D2.068
NM_000386Bleomycin hydrolase (BLMH)2.079
NM_006330Lysophospholipase 1 (LYPLA1)2.088
D21262KIAA0035 gene2.089
NM_003796RPB5-mediating protein (RMP)2.091
NM_004904cAMP response element-binding protein (CRE-BPa)2.096
AF012086Ran binding protein 2 (RanBP2alpha)2.118
NM_005836Translational inhibitor protein p14.5 (UK114)2.126
NM_003998Heat shock 70 ku protein 8 (HSPA8)2.138
NM_000816Gamma-aminobutyric acid (GABA)A receptor, gamma 2 (GABRG2)2.174
NM_003129Squalene epoxidase (SQLE)2.174
NM_022171T-cell leukemia translocation altered gene (TCTA)2.211
NM_006644Heat shock 105 ku (HSP105B)2.256
AF070674Inhibitor of apoptosis protein-1 (MIHC)2.281
NM_001892Casein kinase 1, alpha 1 (CSNK1A1)2.285
NM_001539Heat shock protein, DNAJ-like 2 (HSJ2)2.303
NM_013943Chloride intracellular channel 4 (CLIC4)2.325
NM_006407Vitamin A responsive; cytoskeleton related (JVVA)2.370
NM_014637T-cell receptor rearranged beta chain gene V-region (V-D-J)V-beta-AT2.395
M11952Nuclear receptor subfamily 3, group C, member 1 (NR3C1)2.396
NM_007268Ig superfamily protein (Z391G)2.445
NM_021129Pyrophosphatase (inorganic) (PP), nuclear gene encoding mitochondrial protein2.498
NM_002731Protein kinase, cAMP-dependent, catalytic, beta (PRKACB)2.525
D85606Gene for cholecystokinin type-A receptor2.635
NM_024824Hypothetical protein FLJ11806 (FLJ11806)2.730
AF072928Myotubularin related protein 62.802
Table 4 Down-regulated genes by HCV core.
Accession numbersProteinCy5/Cy3
NM_001961Eukaryotic translation elongation factor 2 (EEF2)0.040
NM_002313Actin binding LIM protein 1 (LIM), transcript variant ABLIM-10.214
NM_014680KIAA0100 gene product (KIAA0100)0.234
NM_003682MAP-kinase activating death domain (MADD)0.259
NM_001226Prosaposin0.266
NM_004728DEAD/H box polypeptide 21 (DDX21)0.313
NM_013975Ligase III, DNA, ATP-dependent (LIG3)0.317
NM_014889Metalloprotease 1 (MP1)0.347
NM_005770Small EDRK-rich factor 2 (SERF2)0.348
NM_005167Ras homolog gene family, member C (ARHC)0.368
NM_000208Insulin receptor (INSR)0.369
NM_003330Thioredoxin reductase 1 (TXNRD1)0.373
NM_005243Ewing sarcoma breakpoint region 1 (EWSR1)0.396
NM_016250N-myc downstream-regulated gene 2 (NDRG2)0.404
NM_001250Tumor necrosis factor receptor superfamily, member 5 (TNFRSF5)0.406
NM_003313Tissue specific transplantation antigen P35B (TSTA3)0.416
NM_004127G protein pathway suppressor 1 (GPS1)0.416
NM_002708Protein phosphatase 1, catalytic subunit, alpha isoform (PPP1CA)0.431
NM_001777CD47 antigen (Rh-related antigen, integrin-associated signal transducer0.444
NM_002199Interferon regulatory factor 2 (IRF2)0.454
NM_002087Granulin (GRN)0.469
NM_000660Transforming growth factor, beta 1 (TGFB1)0.475
NM_054012Argininosuccinate synthetase (ASS)0.478
NM_002084Glutathione peroxidase 3 (GPX3)0.493