Expression of some tumor associated factors in human carcinogenesis and development of gastric carcinoma

doi:10.3748/wjg.v11.i21.3217

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Jun 7, 2005 (publication date) through Nov 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Gastric Cancer

World J Gastroenterol. Jun 7, 2005; 11(21): 3217-3221
Published online Jun 7, 2005. doi: 10.3748/wjg.v11.i21.3217

Table 1 Specification of primer sets for polymerase chain reaction analysis.

Primer	Sequence	PCR product (bp)
IGF-1	5-CAACAAGCCCACAGGGTATGGC-3’
	3-GGAAACGAGACGTGCTCAATGGACA-5’	312
IGF-1R	5-ATGCTGTTTGAACTGATGCGCA-3’
	3-GCCCCCGGCGTTCTTGCTCGCC-5’	354
Gastrin	5-GTCTATGTGCTGATCTTTGCACTG-3’
	3-CTTGGTTCGAAGTCTCGGATCGGT-5’	323
CCK-BR	5-GTGGCCTACGGGCTTATCTCTCGCGAGCTCTACTTA-3’
	3-GACACAACCAACGGTCAAATATCACGGTTGTGCA-5’	357
β-actin	5-GGCGGCACCACCATGTACCCT-3’
	3-TCATACTGCTCAGGCCGGGGA-5’	202

Full Size Table

Table 2 mRNA expression of IGF-1/IGF-1R and gastrin/CCK-BR in gastric cancer tissues and normal mucosa from controls (mean±SE).

Type of specimen	samples	IGF-1/β-actin	IGF-1R/β-actin	Gastrin/β-actin	CCK-BR/β-actin
Cancer tissues	56	0.305±0.032^b	0.129±0.011^b	0.293±0.031^b	0.159±0.018^b
Controls	56	0.154±0.013	0.027±0.004	0.169±0.017	0.058±0.006

^bP<0.01 vs normal mucosa from controls.

Full Size Table

Table 3 mRNA expression of IGF-1/IGF-1R and gastrin/CCK-BR in three kinds of tissues from 56 patients with gastric carcinoma (mean±SE).

Test factor/β-actin	Cancer tissue	Adjacent mucosa	Tumor free
IGF-1/β-actin	0.305±0.028^c	0.220±0.023^a	0.149±0.012
IGF-1R/β-actin	0.129±0.011^c	0.089±0.007^a	0.047±0.006
Gastrin/β-actin	0.284±0.024^c	0.182±0.014	0.133±0.043
CCK-BR/β-actin	0.169±0.016^a	0.144±0.013^a	0.049±0.014

^aP<0.05 vs tumor-free tissues.

^cP<0.05 vs adjacent mucosa.

Full Size Table

Citation: Zhao MD, Hu XM, Sun DJ, Zhang Q, Zhang YH, Meng W. Expression of some tumor associated factors in human carcinogenesis and development of gastric carcinoma. World J Gastroenterol 2005; 11(21): 3217-3221
URL: https://www.wjgnet.com/1007-9327/full/v11/i21/3217.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i21.3217