Efficacy of Chinese medicine Yi-gan-kang granule in prophylaxis and treatment of liver fibrosis in rats

Table 1 Effects of Yi-gan-kang on HSC proliferation.

Group	Concentration (g/L)	A	Proliferation rate
Yi-gan-kang	144	0.08±0.02b	21.62
	72	0.15±0.04b	40.54
	36	0.20±0.03a	54.06
	18	0.17±0.02a	45.95
	9	0.19±0.05a	51.35
	4.5	0.31±0.04	83.78
Control		0.37±0.08	100

^aP<0.05,

^bP<0.01 vs control group.

Table 2 Effects of Yi-gan-kang on HSC proliferation at different time points (mean±SD).

Group	24 h	48 h	72 h
Control	1.44±0.12	2.23±0.18	2.34±0.15
Yi-gan-kang	1.20±0.11	1.26±0.10	1.36±0.08

Table 3 Apoptosis index of Yi-gan-kang on HSC (mean±SD).

Group	Herb concentration (g/L)	Apoptosis index (%)
Yi-gan-kang	36	13.3±0.7b
	18	10.7±0.7b
	9	10.1±0.7b
Control		4.1±0.7

^bP<0.01 vs control group.

Table 4 Time-dependent effects of Yi-gan-kang on HSC apoptosis at different time points (mean±SD).

Group	24 h	48 h	72 h
Control	4.5±1.3	7.1±1.9	8.0±1.8
Yi-gan-kang	9.3±1.8b	10.7±2.7b	14.6±4.3b

^bP<0.01 vs control group.