Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand

Table 1 Demographic and clinical data of 332 patients with chronic HBV infection.

Diagnosis	n	Sex (m/f)	Age (yr)	ALT (U/L)	HBeAg positive	Genotype
						A	B	C	U
Carrier	93	57/36	30.9±10.6	27.5±4.5	42/82 (51.2)	2 (2.2)	16 (17.2)	73 (78.4)	2 (2.2)
CH	103	84/19	36.2±10.1	157.4±103.8	61/92 (66.3)	5 (4.9)	20 (19.4)	76 (73.8)	2 (1.9)
Cirrhosis	60	47/13	48.8±13.8	135.0±90.9	26/53 (49.1)	2 (3.3)	10 (16.7)	44 (73.3)	4 (6.7)
HCC	76	60/16	54.4±12.9	107.8±107.4	15/71 (21.1)	2 (2.6)	23 (30.3)	50 (65.8)	1 (1.3)

CH, chronic hepatitis; HCC, hepatocellular carcinoma; U, unclassified genotype. Quantitative variables are expressed as mean±SD; categorical variables are expressed as n (%).

Table 2 Demographic and clinical data of patients with chronic hepatitis.

Characteristics	Genotype B (n = 20)	Genotype C (n = 76)	P
Age (yr)	35.1±9.6	36.4±10.3	NS
Sex (male/female)	16/4	65/11	NS
Total bilirubin (mg/dL)	0.8±0.2	0.7±0.3	NS
ALT (IU/L)	119.8±58.5	159.8±106.4	0.03
HBeAg positive	8/18 (44.4)	53/74 (71.6)	0.03
HBV DNA (LGE/mL)	7.25±1.74	7.10±1.34	NS
HAI inflammation	5.8±2.1	6.7±2.1	NS
HAI fibrosis	1.5±1.0	1.8±0.9	NS

Quantitative variables are expressed as mean±SD. Categorical variables are expressed as n (%). HAI inflammation, sum of necroinflammatory scores of histology activity index. HAI fibrosis, sum of fibrosis scores of histology activity index.

Table 3 Demographic and clinical data of patients with cirrhosis.

Characteristics	Genotype B (n = 10)	Genotype C (n = 44)	P
Age (yr)	54.7±9.2	47.4±14.4	0.06
Sex (male/female)	8/2	35/9	NS
Total bilirubin (mg/dL)	1.4±0.8	2.2±1.2	NS
ALT (IU/L)	101.5±49.0	133.7±93.4	NS
Albumin (g/dL)	3.7±0.4	3.8±0.5	NS
HBeAg positive	1/9 (11.1)	25/44 (56.8)	0.01
HBV DNA (LGE/mL)	6.59±1.20	7.05±2.50	NS
Child classification (A/B/C)	7/2/1	24/15/5	NS

Quantitative variables are expressed as mean±SD. Categorical variables are expressed as n (%).

Table 4 Demographic and clinical data of patients with HCC.

Characteristics	Genotype B (n = 23)	Genotype C (n = 50)	P
Age (yr)	61.1±9.8	51.3±13.1	0.001
Sex (male/female)	20/3	38/12	NS
Total bilirubin (mg/dL)	2.1±2.0	2.9±4.9	NS
ALT (IU/L)	95.5±102.6	121.4±126.1	NS
Albumin (g/dL)	3.4±0.7	3.5±0.5	NS
HBeAg positive	4/22 (18.1)	11/49 (22.4)	NS
HBV DNA (LGE/mL)	6.71±1.62	6.52±2.63	NS
AFP (IU/mL)	42 485.2±95 590.9	42 032.6±89 382.8	NS
CLIP score (0-1/2-3/4-6)	5/7/11	8/25/17	NS

Quantitative variables are expressed as mean±SD. Categorical variables are expressed as n (%).

Table 5 Multivariate analysis of unfavorable factors of survival in patients with HCC, by using Cox regression analysis.

Factors	Risk ratio	95%CI	P
CLIP stage	4.63	1.70-12.62	0.003
No therapy	6.22	2.54-15.22	0.001