Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux

Table 1 Macroscopic and histological features at baseline.

	NERD	ERD
Number	9	6
Sex (M/F)	3/6	3/3
Mean age ± SD (range)	40.8±12.97 (28-64)	44.3±9.69 (28-53)
Macroscopic findings
Hiatal hernia	8	4
Grade 0	9	0
Grade A	0	0
Grade B	0	5
Grade C	0	1
Grade D	0	0
Histology
Normal	9	0
Mild	0	5
Moderate	0	1
Severe	0	0

Table 2 Mean value of DIS and grading of symptoms in 2 patients with an incomplete healing of mucosa after 3 mo of therapy and outcome after 3 further months of treatment.

	Endoscopy (L. A.)	Mean value of DIS ± SD (mm)	Frequency of symptoms	Severity of symptoms
Patient 1 (female)
Baseline	0	2.14±0.81	5	4
After 3 mo	0	1.21±0.41	1	1
After 3 further mo	0	0.51±0.08	0	0
Patient 2 (female)
Baseline	C	2.61±1.01	5	4
After 3 mo	0	1.15±0.42	3	2
After 3 further mo	0	0.92±0.12	1	1