Nishi Y, Isomoto H, Mukae H, Ishimoto H, Wen CY, Wada A, Ohnita K, Mizuta Y, Murata I, Hirayama T, Nakazato M, Kohno S. Concentrations of α- and β-defensins in gastric juice of patients with various gastroduodenal diseases. World J Gastroenterol 2005; 11(1): 99-103 [PMID: 15609405 DOI: 10.3748/wjg.v11.i1.99]
Corresponding Author of This Article
Dr. Hajime Isomoto, Gastrointestinal Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Jackson 706, 55 Fruit Street, Boston, MA 02114, USA. hajimei2002@yahoo.co.jp
Article-Type of This Article
H Pylori
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World J Gastroenterol. Jan 7, 2005; 11(1): 99-103 Published online Jan 7, 2005. doi: 10.3748/wjg.v11.i1.99
Table 1 Plasma human neutrophil peptides 1-3, β-defensin-2 and β-defensin-1 levels in patients with various gastroduodenal diseases (mean±SD).
Human neutrophil peptides 1-3 (ng/mL)
b-defensin 2 (pg/mL)
b-defensin-1 (ng/mL)
Chronic gastritis
520.8±0.0
250.4±4.1
8.68±.08
Gastric ulcer
512.1±5.3
225.3±2.6
8.81±.26
Duodenal ulcer
560.4±21.9
269.8±6.5
8.37±.14
Benign gastric polyp
606.4±9.5
206.2±0.0
7.81±.32
Normal mucosa
552.7±9.5
196.3±5.4
7.08±.88
Table 2 Plasma human neutrophil peptides 1-3, β-defensin-2 and β-defensin-1 levels and H pylori status (mean±SD).
H pylori-infected
H pylori-uninfected
Human neutrophil peptides 1-3 (ng/mL)
544.2±6.4
518.3±3.1
b-defensin 2 (pg/mL)
286.5±5.8
238.5±3.4
b-defensin 1 (ng/mL)
7.66±0.94
8.13±0.71
Table 3 Plasma pepsinogen I and II levels, pepsinogen I/II ratio and gastrin concentrations in patients with various gastroduodenal diseases (mean±SD).
Pepsinogen I (ng/mL)
Pepsinogen II (ng/mL)
Pepsinogen I/II ratio
Gastrin (pg/mL)
Chronic gastritis
52.0±26.5
19.5±9.8
3.3±1.9
84.9±41.3
Gastric ulcer
67.1±31.2
31.4±12.5
2.4±1.3
69.3±35.9
Duodenal ulcer
76.7±20.2
18.1±8.9
4.5±0.8
69.2±34.6
Benign gastric polyp
49.0±29.1
17.3±16.9
4.0±2.8
57.1±30.4
Normal mucosa
46.7±26.2
9.2±5.4
5.2±1.5
48.5±22.1
Table 4 Plasma pepsinogen I and II levels, pepsinogen I/II ratio and gastrin concentrations with respect to H pylori status.
Pepsinogen I (ng/mL)
Pepsinogen II (ng/mL)
Pepsinogen I/II ratio
Gastrin (pg/mL)
H pylori-infected
62.9±25.6
23.5±11.4
3.1±2.5
76.1±39.7
H pylori-uninfected
42.5±23.2
8.6±4.9
5.2±3.4
56.2±27.7
Table 5 Correlation coefficients between each parameter.
Pepsinogen I (ng/mL)
Pepsinogen II (ng/mL)
Pepsinogen I/II ratio
Gastrin (pg/mL)
Human neutrophil peptides 1-3
-0.492
0.043
-0.418
-0.265
b-defensin 2
0.073
0.297
-0.321
0.087
b-defensin 1
-0.114
0.023
-0.175
0.14
Citation: Nishi Y, Isomoto H, Mukae H, Ishimoto H, Wen CY, Wada A, Ohnita K, Mizuta Y, Murata I, Hirayama T, Nakazato M, Kohno S. Concentrations of α- and β-defensins in gastric juice of patients with various gastroduodenal diseases. World J Gastroenterol 2005; 11(1): 99-103