Amelioration of hemodynamics and oxygen metabolism by continuous venovenous hemofiltration in experimental porcine pancreatitis

doi:10.3748/wjg.v11.i1.127

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Jan 7, 2005 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2005; 11(1): 127-131
Published online Jan 7, 2005. doi: 10.3748/wjg.v11.i1.127

Table 1 Clinical parameters (mean±SD).

Parameter	Group	Baseline	6 h	12 h	24 h	36 h	48 h
HR(bpm)	1	123.0±8.2	179±9.7^d	194±20.8^d	164±26.2^c	132±23.0	NC
	2	123.0±8.2	159±10.4^a^d	165±15.5^a^d	159±21.6^d	139±25.2	141±36.1
	3	125.0±8.3	149±9.9^a^d	155±23.8^a^d	148±21.4^d	148±17.6^d	138±18.4
BT(°C)	1	37.1±1.2	39.6±1.1^d	40.0±0.9^d	36.0±0.6^c	35.6±0.6	NC
	2	37.9±0.7	38.7±1.2	38.7±0.6^a	36.8±1.2^c	36.1±1.3	37.5±3.4
	3	37.8±0.5	38.3±0.6^a^c	38.6±0.8^a	38.8±0.8^a^c	38.5±0.2^a^c	39.0±0.3
Amy(U/l)	1	238.3±122.6	3635.0±427.2^d	9535.8±5802.6^d	7535.7±6573.6^c	5502.7±1976.8^c	NC
	2	336.0±123.8	3309.1±1331.2^d	8199.4±5881.0^d	8441.8±5730.6^d	2960.5±1292.6^c	3168.5±1136.3
	3	237.0±66.7	2803.9±518.1^d	8186.6±3987.9^d	8265.3±4092.0^d	3211.9±1151.7^d	2161.3±814.6

HR: heart rate, BT: body temperature, Amy: amylase. Group 1: controls; group 2: low-volume continuous veno-venous hemofiltration (CVVH) (20 mL/kg body weight [BW]/h); group 3: high-volume CVVH (100 mL/kg BW); NC, not calculated (no survival).

^aP<0.05 and ^bP<0.01 vs the respective value in controls;

^cP<0.05 and

^dP<0.01 vs baseline values, respectively.

Table 2 Hemodynamic parameters (mean±SD).

Parameter	Group	Baseline	6 h	12 h	24 h	36 h	48 h
MAP (mmHg)	1	126.5±7.76	95.5±10.20^d	87.38±12.45^d	81.83±5.08^d	80.0±10.0^d	NC
	2	126.3±7.19	95.6±7.44^d	104.5±6.82^a^d	102.0±10.64^a^d	100.8±9.74^a^c	84.5±13.44
	3	123.3±4.43	117.8±9.07^a^c	116.3±7.80^a	106.8±9.79^a^d	104.5±6.74^a^d	99.57±11.97
MPAP (mmHg)	1	24.5±1.51	25.0±1.07	26.8±1.16^d	30.0±2.76^d	27.3±3.06	NC
	2	24.3±2.25	26.1±2.59	26.4±2.33	28.4±3.58^c	29.5±2.38	29.0±8.49
	3	24.4±1.85	25.9±1.25	22.1±1.81^a	25.4±2.92^a	27.3±3.58^c	27.4±1.72
PCWP (mmHg)	1	10.1±1.96	9.1±2.85	10.8±1.98	14.2±3.19^c	11.0±2.65	NC
	2	10.5±1.60	9.0±4.14	11.5±3.25	11.8±4.17	11.5±7.14	8.5±4.95
	3	10.3±0.71	8.8±1.98	9.6±1.60	10.3±2.87^a	10.0±3.82	14.0±3.00
CVP (mmHg)	1	8.6±2.07	7.3±2.12	5.5±2.07^c	9.2±3.92	9.0±1.73	NC
	2	8.0±2.14	8.6±4.41	7.6±3.85	8.6±2.50	11.5±6.24	7.0±5.66
	3	7.9±1.36	6.5±1.93	6.9±1.36	7.3±1.98	7.4±2.07	8.3±2.21
CI (L/min/m²)	1	4.5±0.55	6.2±0.64^d	5.9±1.19^c	3.1±0.41^d	2.4±0.70	NC
	2	4.7±0.75	5.4±0.90^c	5.9±0.86^c	5.1±1.79^a	4.6±2.43	3.7±0.12
	3	4.6±0.54	5.0±0.97^a	4.2±0.73^a	4.8±0.56^a	5.3±1.10^a	6.3±1.17
SVR (dyn.s.m^-5)	1	2130.2±204.5	1176.8±253.9^d	1465.0±788.3^c	1915.8±397.8	3617.7±374.1^d	NC
	2	2061.2±407.1	1329.6±354.8^d	1349.9±218.6^d	1573.0±633.1	1988.1±942.4^a	1674.2±463.6
	3	2034.4±315.6	1820.8±380.3^a	2172.3±371.7^a	1664.6±268.1	1512.6±321.6^a	1187.4±201.4

MAP: mean arterial pressure, MPAP: mean pulmonary artery pressure, PCWP: pulmonary capillary wedge pressure, CVP: central venous pressure, CI: cardiac index, SVR: systemic vascular resistance. Group 1: controls; group 2: low-volume continuous veno-venous hemofiltration (CVVH) (20 mL/kg body weight [BW]/h); group 3: high-volume CVVH (100 mL/kg BW); NC, not calculated (no survival).

^aP<0.05 and ^bP<0.01 vs the respective value in controls;

^cP<0.05 and

^dP<0.01 vs baseline values, respectively.

Table 3 Oxygen metabolism parameters (mean±SD).

Parameter	Group	Baseline	6 h	12 h	24 h	36 h	48 h
DO₂	1	774.1±142.9	1044.5±154.2^d	1029.4±307.6	501.3±75.0^d	389.4±178.8	NC
	2	751.4±206.0	811.6±197.4^a	840.6±195.7	673.6±189.8	458.4±166.8^c	320.9±71.8
	3	674.2±76.7	706.5±95.4^a	552.1±119.7^a	489.5±71.8^b^d	474.9±63.0^d	517.2±163.7
VO₂	1	215.3±44.9	336.6±103.1^d	331.4±153.2	140.0±46.4^d	108.0±55.1^c	NC
	2	224.4±67.0	365.9±136.4^d	331.0±70.0^d	293.1±105.4^a	200.6±133.8	93.7±41.9
	3	203.7±61.1	366.1±52.6^d	247.8±73.7^b	178.5±44.0^b	163.2±45.1	167.8±90.0
OER	1	27.8±2.0	31.7±7.7	31.5±6.7	27.6±7.2	27.6±3.1	NC
	2	29.9±4.6	44.0±9.0^a^d	40.0±5.8^a^c	43.5±10.4^a^c	41.0±12.9	28.5±6.7
	3	30.0±6.8	51.9±3.2^a^d	44.6±7.3^a^d	36.3±7.2^a^d	33.9±6.4	31.0±7.8

DO₂: oxygen delivery, VO₂: oxygen consumption, OER: oxygen extraction ratio. Group 1: controls; group 2: low-volume continuous veno-venous hemofiltration (CVVH) (20 mL/kg body weight [BW]/h); group 3: high-volume CVVH (100 mL/kg BW); NC, not calculated (no survival).

^aP<0.05 and

^bP<0.01 vs the respective value in controls;

^cP<0.05 and

^dP<0.01 vs baseline values, respectively.

Citation: Wang H, Zhang ZH, Yan XW, Li WQ, Ji DX, Quan ZF, Gong DH, Li N, Li JS. Amelioration of hemodynamics and oxygen metabolism by continuous venovenous hemofiltration in experimental porcine pancreatitis. World J Gastroenterol 2005; 11(1): 127-131
URL: https://www.wjgnet.com/1007-9327/full/v11/i1/127.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i1.127