Pathobiological behavior and molecular mechanism of signet ring cell carcinoma and mucinous adenocarcinoma of the stomach: A comparative study

Table 1 The comparison of pathobiologic characteristics between SRC and mucinous adenocarcinoma

Pathobiologic characteristics	SRC (AMPFDT)	Mucinous adenocarcinoma
		AMPFDT	MSFDT
Onset age	Mostly below 50	Same as the left	Mostly over 50[1,2]
Sex	more in female	Same as the left	More in male[1,2]
Infiltrative depth	16.7% (2/12) passing		70.0% (7/10) passing
	through the serosa		through the serosa[1,2]
Growth pattern	Diffuse growth 100.0% (12/12)		Diffuse growth 40.0% (4/10),
			massive growth 60.0% (6/10)[1,2]
Metastasis rate of lymph node	66.7% (8/12)		80.0% (8/10)[1,2]
Distant metastasis	Often to ovary and uterus, sometimes	Same as the left	Prone to peritoneal
	to bones, marrow, bladder, blepharon		extensive infiltration[1,2]
	or skin of lower extremities
Tumor related markers
ER	Positive rate 75.0% (9/12)		Positive rate 10.0% (1/10)[1,2]
c-PDE	Positive rate 80.0% (4/5)		Positive rate 20.0% (1/5)[3]
LN	Few, positive rate 25.0% (2/8)		BM*-like line structure was seen
			frequently, positive rate 83.3% (5/6)[4]
67 KDa LN-R	Positive rate 75.0% (15/20)		Positive rate 25.0% (1/4)[5]
Collagen IV	CN-IV positive fragments or particles		BM*-like line structure was seen frequently
	only, positive rate 87.5% (7/8)		Positive rate 100.0% (6/6)[4]
CD44V6	Positive rate 11.8% (2/17)		Positive rate 62.5% (5/8)[6]
PTEN	Low expression (25.0%, 7/21)		High expression (60.0%) 6/10[8]
VEGF	Positive rate 90.0% (9/10)		Positive rate 100.0% (7/7)[7]
ECD	Negative expression 85.0% (17/20)		Negative rate 75.0% (3/4)[9]
DNA ploidy	Polyploid and heteroploid were often		Polyploid and heteroploid were
	seen in early stage, while diploid and		often observed[10]
	hypodiploid were often seen in advanced stage
mtDNA variation	66.7% (2/3), para-cancerous		66.7% (2/3), para-cancerous
D-loop region	tissue 33.3% (1/3)		tissue 66.7% (2/3)
12S rRNA	33.3% (1/3)		66.7% (2/3)[11]
Ultrastructure	More mucous secretion. Few desmosome		Plenty of mucous secretion.
	junctions and gap junctions between cells.		Several desmosome junctions and
			gap junctions between cells
5 year survival rate	15.9%		19.4%

*Basement membrane.