Liver Cancer
Copyright ©The Author(s) 2004.
World J Gastroenterol. Dec 15, 2004; 10(24): 3559-3563
Published online Dec 15, 2004. doi: 10.3748/wjg.v10.i24.3559
Table 1 Status of p53 gene from liver and tumor tissues of tree shrews
Animal (Groups)Treatment
TissuesGrade of tumorsStatus of p53 geneChange of nucleic acid
HBVAFB1
5201 (C)-+liver-wt-
5207 (C)-+tumorIwt-
5063 (A)++tumorIImt (78)GCA-GCG
5067 (A)++tumorIIwt-
5172 (A)++tumorIIImt (13)CCT-CTT
5173 (A)++tumorIImt (275)TGT-CGT
1 (D)--liver-wt-
2 (D)--liver-wt-
Table 2 Expression of p21 in normal liver and liver tumor tissues of tree shrews
GroupNo. of animals (n)incidence of HCC (%)p21+
p21-
Animal (n)Incidence of HCC (%)Animal (n)Incidence of HCC (%)
A3923 (58.97)bd1616 (100.0)af237 (30.43)fj
B281 (3.57)20261 (3.84)
C296 (20.68)74 (54.14)h222 (9.09)
D2000200
Table 3 Relationship between p21 expression and HCC de-velopment
GroupAnimal (n)HCC (n)Rate of HCC (%)
p21-positive252080.0b
p21-negative911010.99