Effects of dendritic cells transfected with full-length wild-type p53 and stimulated by gastric cancer lysates on immune response

doi:10.3748/wjg.v10.i17.2595

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 17

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3364)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

292

HTML

2187

Figures (1-1)

422

Tables (1-3)

463

Sum=3364

Sep 1, 2004 (publication date) through Oct 30, 2025

Times Cited of This Article

Times Cited (3)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Brief Reports

World J Gastroenterol. Sep 1, 2004; 10(17): 2595-2597
Published online Sep 1, 2004. doi: 10.3748/wjg.v10.i17.2595

Table 1 Surface molecules expression of 4 kinds of DCs stimulated with lysates (n = 10, mean ± SD, %)

Surface molecules	DC	Wtp53DC	LyDC	Lywtp53
B7-1	36.70 ± 0.07	61.77 ± 0.08	67.20 ± 0.05	86.70 ± 0.07^a
B7-2	5.27 ± 0.01	9.90 ± 0.04	9.13 ± 0.03	18.77 ± 0.08^a
MHC-I	44.03 ± 0.04	69.13 ± 0.05	68.10 ± 0.03	87.20 ± 0.05^a
MHC-II	17.13 ± 0.12	31.10 ± 0.31	32.73 ± 0.23	56.70 ± 0.07^a

^aP < 0.05 vs any group of DC, wtp53DC and LyDC.

Full Size Table

Table 2 Immune protection of DCs (mean ± SD, n = 10)

Group	Tumor diameter after inoculation (mm)
Group	d 10	d 13	d 16	d 19
Control	3.72 ± 0.01	6.70 ± 0.02	7.10 ± 0.09	9.90 ± 0.02
DC	3.70 ± 0.01	5.70 ± 0.08	6.10 ± 0.04	9.70 ± 0.08
Wtp53DC	3.07 ± 0.01	6.90 ± 0.04	7.13 ± 0.03	8.22 ± 0.08
LyDC	4.03 ± 0.04	6.13 ± 0.05	7.10 ± 0.03	8.77 ± 0.05
Lywtp53	3.13 ± 0.02	3.10 ± 0.31^a	2.73 ± 0.23^a	3.70 ± 0.07^a

^aP < 0.05 vs control, DC, wtp53DC and LyDC group.

Full Size Table

Table 3 Immune treatment of DCs (mean ± SD, n = 10)

Group	Tumor diameter after inoculation (mm)
Group	d 7	d 12	d 15	d 18
Control	5.72 ± 0.02	7.88 ± 0.09	9.20 ± 0.11	11.90 ± 0.09
DC	4.70 ± 0.03	7.71 ± 0.08	9.02 ± 0.04	10.70 ± 0.68
Wtp53DC	5.03 ± 0.09	6.90 ± 0.09	7.13 ± 0.11	8.29 ± 0.05
LyDC	5.06 ± 0.01	6.13 ± 0.08	7.10 ± 0.05	8.77 ± 0.03
Lywtp53	5.19 ± 0.09	5.10 ± 0.39	6.73 ± 0.66^a	6.79 ± 0.77^a

^aP < 0.05 vs control, DC, wtp53DC and LyDC group.

Full Size Table

Citation: Sun HW, Tang QB, Cheng YJ, Zou SQ. Effects of dendritic cells transfected with full-length wild-type p53 and stimulated by gastric cancer lysates on immune response. World J Gastroenterol 2004; 10(17): 2595-2597
URL: https://www.wjgnet.com/1007-9327/full/v10/i17/2595.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i17.2595