Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells

doi:10.3748/wjg.v10.i13.1911

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Jul 1, 2004 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 1, 2004; 10(13): 1911-1913
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1911

Table 1 Effect of different BOL dosage sera on ³H-TdR incor-poration of normal rat HSCs (mean ± SD)

Groups	n	Cpm/well	Inhibitory rate (%)
Control	6	2846.31 ± 218.92
Colchicine	6	2018.37 ± 39.31^b	29.12 ± 2.85
Low-dose	6	1968.42 ± 78.32^b	30.84 ± 2.71
Intermediate-dose	6	1870.21 ± 109.45^b	34.56 ± 4.21^a^,^d
High-dose	6	1779.86 ± 61.12^a^,^d^,^f	37.82 ± 1.32^d^,^f

^aP < 0.05 vs low-dose group,

^bP < 0.01 vs control group,

^dP < 0.01 vs colchicine group,

^fP < 0.01 vs low-dose group.

Table 2 Effect of different BOL dosage sera on ³H-TdR incor-poration of hepatofibrotic rat HSCs (mean ± SD)

Groups	n	Cpm/well	Inhibitory rate (%)
Control	6	1657.82 ± 67.21
Colchicine	6	1022.54 ± 12.18^b	38.32 ± 2.65
Low-dose	6	994.69 ± 37.86^b	40.15 ± 5.36
Intermediate -dose	6	828.91 ± 48.19^b^,^d^,^f	51.31 ± 3.14^d^,^f
High-dose	6	662.59 ± 17.87^b^,^d^,^f	60.15 ± 5.36^d^,^f

^bP < 0.01 vs control group,

^dP < 0.01 vs colchicine group,

^fP < 0.01 vs low-dose group.

Table 3 Effect of different concentration sera containing inter-mediate dosage of BOL on ³H-TdR incorporation of normal rat HSCs (mean ± SD)

Concentration	n	Control group	BOL group	Inhibitory
Concentration	n	(cpm/well)	(cpm/well)	rate (%)
50 mL/L	6	1479.79 ± 171.01	701.19 ± 134.25^a	50.82 ± 9.28
100 mL/L	6	1990.80 ± 601.42	640.11 ± 209.69^a	69.02 ± 9.96^c
200 mL/L	6	2699.89 ± 789.10	479.59 ± 257.30^a	81.78 ± 8.92^b

^aP < 0.05 vs control group,

^bP < 0.01 vs 50 mL/L concentration,

^cP < 0.05 vs 50 mL/L concentration.

Table 4 Effect of different concentration sera containing intermediate dosage of BOL on ³H-TdR incorporation of hepatofibrotic rat HSCs (mean ± SD)

Concentration	n	Control group	BOL group	Inhibitory
Concentration	n	(cpm/well)	(cpm/well)	rate (%)
50 mL/L	6	987.73 ± 154.02	563.07 ± 124.38^a	61.38 ± 7.16
100 mL/L	6	1342.58 ± 701.36	375.92 ± 109.47^a	72.19 ± 10.96^c
200 mL/L	6	2306.39 ± 652.14	299.83 ± 123.51^a	87.16 ± 8.54^b

^aP < 0.05 vs control group,

^bP < 0.01 vs 50 mL/L concentration,

^cP < 0.05 vs 50 mL/L concentration.

Citation: Yao L, Yao ZM, Weng H, Zhao GP, Zhou YJ, Yu T. Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells. World J Gastroenterol 2004; 10(13): 1911-1913
URL: https://www.wjgnet.com/1007-9327/full/v10/i13/1911.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i13.1911