Influence of serum collected from rat perfused with compound Biejiaruangan drug on hepatic stellate cells

doi:10.3748/wjg.v10.i10.1487

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May 15, 2004 (publication date) through Feb 24, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. May 15, 2004; 10(10): 1487-1494
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1487

Table 1 Influence of each group serum on proliferation of HSC at different time points (A value: mean ± SD)

	N	M	G	Z	D
24 h	0.40 ± 0.06	0.40 ± 0.03	0.38 ± 0.03	0.391 ± 0.02	0.38 ± 0.03
48 h	0.52 ± 0.03^c	0.66 ± 0.05^a	0.47 ± 0.02^a^c	0.460 ± 0.02^a^c	0.51 ± 0.03^c
72 h	0.75 ± 0.09^c	0.96 ± 0.05^a	0.55 ± 0.07^a^c	0.580 ± 0.08^a^c	0.69 ± 0.07^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 2 Influence of each group serum on α-SMA of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	619.89 ± 163.84^c	7.49 ± 2.06^c	778.93 ± 190.26^a	9.64 ± 0.26^a	110.95 ± 45.21^a^c	0.90 ± 0.22^a^c	243.83 ± 62.97^a^c	2.72 ± 1.48^a^c	417.46 ± 126.72^c	3.56 ± 0.91^c
48 h	812.51 ± 123.39^c	8.28 ± 4.58^c	1032.69 ± 106.64^a	10.56 ± 1.83^a	333.71 ± 57.9^a^c	1.55 ± 0.29^a^c	345.08 ± 51.85^a^c	3.66 ± 1.67^a^c	675.35 ± 202.20^c	5.45 ± 2.50^c
72 h	989.77 ± 166.32^c	9.36 ± 2.39^c	1255.30 ± 150.39^a	15.66 ± 2.34^a	448.36 ± 55.80^a^c	3.25 ± 0.56^a^c	556.27 ± 80.32^a^c	4.66 ± 1.24^a^c	759.38 ± 109.32^a^c	6.99 ± 1.58^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 3 Influence of each group serum on desmin of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	78.93 ± 18.56^c	17.49 ± 2.06^c	119.69 ± 23.84^a	20.64 ± 2.26^a	58.95 ± 5.21^a^c	12.90 ± 3.22^a^c	63.83 ± 12.97^a^c	12.72 ± 1.48^a^c	75.46 ± 26.72^c	13.56 ± 0.91^c
48 h	103.78 ± 36.64^c	10.28 ± 4.58^c	182.51 ± 28.43^a	14.56 ± 1.83^a	63.71 ± 7.94^a^c	8.55 ± 0.29^a^c	65.08 ± 18.85^a^c	7.66 ± 1.67^a^c	79.35 ± 22.28^c	9.35 ± 2.50^c
72 h	125.30 ± 40.39^c	9.36 ± 2.39^c	1255.30 ± 150.39^a	15.66 ± 2.34^a	448.36 ± 55.80^a^c	3.25 ± 0.56^a^c	556.27 ± 80.32^a^c	4.66 ± 1.24^a^c	759.38 ± 109.32^a^c	6.99 ± 1.58^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 4 Influence of each group serum on synapsin of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	396.29 ± 78.56^c	5.49 ± 2.06^c	528.79 ± 26.84^c	12.93 ± 2.33^c	138.92 ± 20.21^a^c	2.64 ± 0.22^a^c	190.87 ± 52.97^a^c	3.69 ± 1.24^a^c	284.54 ± 66.72^c	4.05 ± 0.91^c
48 h	577.78 ± 86.84^c	8.28 ± 4.58^c	748.57 ± 29.73^c	10.56 ± 1.83^c	228.71 ± 71.94^a^c	1.55 ± 0.29^a^c	338.08 ± 108.66^a^c	3.66 ± 1.67^a^c	675.35 ± 202.20^c	5.45 ± 2.50^c
72 h	989.77 ± 166.32^c	9.36 ± 2.39^c	1255.30 ± 150.39^c	15.66 ± 2.34^c	448.36 ± 55.80^a^c	3.25 ± 0.56^a^c	556.27 ± 80.32^a^c	4.66 ± 1.24^a^c	759.38 ± 109.32^a^c	6.99 ± 1.58^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 5 Influence of each group serum on collagen I of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	50.87 ± 9.84	5.49 ± 2.06^c	60.63 ± 9.26	4.64 ± 0.26	46.95 ± 5.21	2.90 ± 0.22	44.83 ± 6.97	3.72 ± 0.48	49.46 ± 7.36	3.89 ± 0.79
48 h	270.51 ± 13.56	5.28 ± 0.58	456.78 ± 106.64	5.56 ± 1.83	107.79 ± 17.9	4.45 ± 0.29	115.28 ± 51.85	4.66 ± 1.67	129.35 ± 22.20	4.45 ± 0.50
72 h	507.77 ± 66.38^c	11.36 ± 2.39^c	800.30 ± 150.39^a	15.66 ± 2.34^a	300.23 ± 25.80^a^c	5.25 ± 0.56^a^c	329.37 ± 45.98^a^c	6.62 ± 1.33^a^c	425.38 ± 19.32^c	7.99 ± 1.25^c

N: Control group; M: Model group; G: High dosage group; Z: Mdium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 6 Influence of each group serum on collagen III of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	60.93 ± 18.56	12.49 ± 3.16	65.69 ± 23.841	3.64 ± 2.36	40.95 ± 5.21	8.90 ± 3.82	45.83 ± 12.97	9.72 ± 1.47	52.46 ± 26.72	10.56 ± 0.56
48 h	203.78 ± 36.64^c	25.28 ± 4.27^c	282.51 ± 28.43^a	31.56 ± 3.69^a	63.71 ± 7.94^a^c	15.55 ± 3.59^a^c	65.08 ± 18.85^a^c	17.66 ± 1.65^a^c	79.35 ± 22.28^a^c	21.35 ± 2.36^a^c
72 h	325.30 ± 40.39^c	30.36 ± 2.50^c	501.77 ± 56.42^a	40.66 ± 4.82^a	178.36 ± 5.82^a^c	23.25 ± 4.26^a^c	182.27 ± 20.32^a^c	25.66 ± 1.29^a^c	220.38 ± 19.32^c	29.70 ± 1.72^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 7 Influence of each group serum on TIMP of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	60.93 ± 18.56	12.49 ± 3.16	65.69 ± 23.84	13.64 ± 2.36	40.95 ± 5.21	8.90 ± 3.82	45.83 ± 12.97	9.72 ± 1.47	52.46 ± 26.72	10.56 ± 0.56
48 h	203.78 ± 36.64^c	25.28 ± 4.27^c	282.51 ± 28.43^a	31.56 ± 3.69^a	63.71 ± 7.94^a^c	15.55 ± 3.59^a^c	65.08 ± 18.85^a^c	17.66 ± 1.65^a^c	79.35 ± 22.28^a^c	21.35 ± 2.36^a^c
72 h	325.30 ± 40.39^c	30.36 ± 2.50^c	501.77 ± 56.42^a	40.66 ± 4.82^a	178.36 ± 5.82^a^c	23.25 ± 4.26^a^c	182.27 ± 20.32^a^c	25.66 ± 1.29^a^c	220.38 ± 19.32^c	29.70 ± 1.72^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 8 Influence of each group serum on TGFβ1 of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	126.56 ± 21.69	5.14 ± 0.69	158.79 ± 27.63	9.67 ± 2.59	98.92 ± 29.25	5.48 ± 0.49	105.69 ± 27.96	6.72 ± 1.74	122.56 ± 67.84	6.21 ± 0.98
48 h	570.78 ± 57.61^c	15.78 ± 0.78^c	733.58 ± 189.73^a	19.39 ± 3.76^a	428.71 ± 51.30^a^c	7.36 ± 0.87^a^c	458.08 ± 37.98^a^c	9.87 ± 1.98^a^c	549.35 ± 124.29^c	13.27 ± 2.77^a
72 h	1279.30 ± 147.78^c	21.98 ± 2.38^c	1509.87 ± 77.50^a	27.58 ± 5.65^a	609.37 ± 72.85^a^c	9.25 ± 0.67^a^c	823.75 ± 158.49^a^c	12.35 ± 1.75^a^c	971.57 ± 127.83^c	19.30 ± 1.36^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 9 Influence of each group serum on PDGF of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	326.47 ± 15.31^c	7.14 ± 0.69	447.69 ± 25.47^a	12.05 ± 3.87	128.87 ± 35.14^a^c	4.21 ± 0.29	187.39 ± 36.67^a^c	7.83 ± 0.67	227.87 ± 54.39^c	9.64 ± 0.87
48 h	479.65 ± 38.49^c	24.78 ± 5.90^c	659.45 ± 76.56^a	37.25 ± 4.89^c	214.17 ± 54.67^a^c	9.28 ± 0.70^a^c	264.58 ± 49.57^a^c	14.02 ± 2.06^a^c	379.27 ± 75.02^c	18.56 ± 3.27^a^c
72 h	805.30 ± 121.04^c	32.98 ± 5.49^c	1208.02 ± 132.21^a	45.94 ± 5.37^c	427.21 ± 39.72^a^c	15.07 ± 2.78^a^c	560.41 ± 132.02^a^c	19.28 ± 2.09^a^c	720.34 ± 102.07^c	27.19 ± 3.29^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Citation: Guo SG, Zhang W, Jiang T, Dai M, Zhang LF, Meng YC, Zhao LY, Niu JZ. Influence of serum collected from rat perfused with compound Biejiaruangan drug on hepatic stellate cells. World J Gastroenterol 2004; 10(10): 1487-1494
URL: https://www.wjgnet.com/1007-9327/full/v10/i10/1487.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i10.1487