Mesenteric artery remodeling and effects of imidapril and irbesartan on it in spontaneously hypertensive rats

Table 1 Blood pressure measured in WKY, SHR, imidapril and irbesartan groups (mean ± SD, n = 10)

Group	Blood pressure (mmHg)
	13-wk-old	14-wk-old	15-wk-old	17-wk-old	19-wk-old	21-wk-old	24-wk-old	26-wk-old
WKY	105.90 ± 16.10d	115.70 ± 9.19	112.00 ± 7.53	90.00 ± 9.13	125.50 ± 7. 62	116.00 ± 6.99	116.00 ± 11.25	121.50 ± 4.74
SHR	134.40 ± 7.72	140.00 ± 17.48	151.00 ± 24.59b	160.00 ± 14.90f	177.00 ± 16.19f	177.50 ± 14.39f	190.00 ± 19.00f	198.10 ± 14.04f
Imidapril	131.50 ± 6.68	124.30 ± 7.02	127.50 ± 8.58	125.00 ± 7.45	130.80 ± 15.16	138.00 ± 12.52	127.00 ± 11.10	142.00 ± 6.32
Irbesartan	140.10 ± 5.90	132.50 ± 15.14	124.00 ± 18.83	122.50 ± 20.17	128.00 ± 12.06	138.00 ± 6.32	126.00 ± 6.15	141.00 ± 14.87

^bP < 0.01 vs WKY, imidapril, irbesartan groups;

^dP < 0.01 vs SHR, imidapril, irbesartan groups;

^fP < 0.01 vs WKY, imidapril, irbesartan groups.

Table 2 Concentration of Ang II in plasma (mean ± SD, n = 7)

Group	Plasma (pg/mL)	Mesenteric artery (pg/100 mg)
WKY	303.15 ± 16.99	2218.63 ± 242.37
SHR	318.77 ± 16.83	2138.48 ± 110.56a
Imidapril	307.43 ± 25.20	1888.92 ± 147.46ce
Irbesartan	571.38 ± 57.89b	3509.18 ± 168.44hfg

^aP < 0.05 vs WKY,

^bP < 0.01 vs WKY, SHR, imidapril group,

^cP < 0.05 vs WKY;

^eP < 0.05 vs SHR;

^fP < 0.01 vs SHR;

^hP < 0.01 vs WKY;

^gP < 0.05 vs imidapril.

Table 3 Comparisons of ratios of intima-media thickness/lumen radius, media/lumen area, lumen/vessel radius in four groups (mean ± SD, n = 7)

Group	Media thickness (mm)/lumen radius (mm)	Media area (mm2)/lumen area (mm2)	Lumen radius (mm)/vessel radius (mm)
WKY	0.75 ± 0.09	0.35 ± 0.04	0.65 ± 0.01
SHR	2.67 ± 0.20a	1.21 ± 0.14a	0.46 ± 0.01a
Imidapril	1.67 ± 0.13ec	0.71 ± 0.05ec	0.51 ± 0.01ec
Irbesartan	1.47 ± 0.27ge	0.65 ± 0.14ge	0.53 ± 0.01ge

^aP < 0.05 vs WKY;

^cP < 0.05 vs SHR;

^eP < 0.05 vs WKY; ^eP < 0.05 vs SHR;

^gP < 0.05 vs WKY.

Table 4 Absorbance of c-Jun/absorbance of GAPDH, absor-bance of TGF-β/absorbance of GAPDH (mean ± SD, n = 5)

Group	Absorbance of c-Jun/absorbance of GAPDH	Absorbance of TGF-β1/absorbance of GAPDH
WKY group	0.582 ± 0.013	0.780 ± 0.018
SHR group	0.850 ± 0.015b	0.887 ± 0.019d
Imidapril group	0.743 ± 0.012a	0.803 ± 0.005c
Irbesartan group	0.789 ± 0.013	0.847 ± 0.017

F = 1 340 in the ratio of absorbance of c-Jun/absorbance of GAPDH.

^aP < 0.05 vs irbesartan group,

^bP < 0.01 vs WKY, imidapril, irbesartan group. F = 198 in the ratio of Absorbance of TGF-β₁/absorbance of GAPDH.

^cP < 0.05 vs irbesartan group,

^dP < 0.01 vs WKY, imidapril, irbesartan group.