Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7489
Revised: September 15, 2013
Accepted: September 16, 2013
Published online: November 21, 2013
Processing time: 154 Days and 17.4 Hours
Adhesive small bowel obstruction (ASBO) is the most frequently encountered surgical disorder of the small intestine. Up to 80% of ASBO cases resolve spontaneously and do not require invasive treatment. It is important to identify such patients that will benefit from conservative treatment in order to prevent unnecessarily exposing them to the risks associated with surgical intervention, such as morbidity and further adhesion formation. For the remaining ASBO patients, timely surgical intervention is necessary to prevent small bowel strangulation, which may cause intestinal ischemia and bowel necrosis. While early identification of these patients is key to decreasing ASBO-related morbidity and mortality, the non-specific signs and laboratory findings upon clinic presentation limit timely diagnosis and implementation of appropriate clinical management. Combining the clinical presentation findings with those from other diagnostic imaging modalities, such as abdominal X-ray, computed tomography-scan and water-soluble contrast studies, will improve diagnosis of ASBO and help clinicians to better evaluate the potential of conservative management as a safe strategy for a particular patient. Nonetheless, patients who present with moderate findings by all these approaches continue to represent a challenge. A new diagnostic strategy is urgently needed to further improve our ability to identify early signs of strangulated bowel, and this diagnostic modality should be able to indicate when surgical management is required. A number of potential serum markers have been proposed for this purpose, including intestinal fatty acid binding protein and α-glutathione S transferase. On-going research is attempting to clearly define their diagnostic utility and to optimize their potential role in determining which patients should be managed surgically.
Core tip: Adhesive small bowel obstruction (ASBO) is a frequently encountered disorder of the small intestine following abdominal surgery. Accurately predicting whether ASBO patients can be treated conservatively is required to prevent exposing patients unnecessarily to surgery-related risks, including morbidity and further adhesion formation. Although recent technological developments have improved the ability to identify those patients most fit for conservative management, the remaining patients with moderate findings upon clinical presentation remain a problem. Serum markers of intestinal ischemia are promising candidates for improving early diagnosis and identification of patients with strangulated bowel, who will benefit most from surgical management.
- Citation: Oudheusden TRV, Aerts BA, Hingh IH, Luyer MD. Challenges in diagnosing adhesive small bowel obstruction. World J Gastroenterol 2013; 19(43): 7489-7493
- URL: https://www.wjgnet.com/1007-9327/full/v19/i43/7489.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i43.7489
Small bowel obstruction (SBO) leading to strangulation and potential bowel necrosis is a serious condition that mandates surgical intervention[1-3]. Timely diagnosis is essential to prevent the associated morbidity and mortality that manifest as operative management is delayed[4]. This fact was highlighted by the adage among surgeons citing “never let the sun rise or set in the case of small bowel obstruction”.
Since up to 80% of SBO cases resolve without incident under conservative treatment[5,6], identification of patients whose obstruction will spontaneously resolve is important to prevent unnecessary surgical intervention and exposure to the risks of procedure-related morbidity and further formation of adhesions[6,7]. Recent technological advances in diagnostic modalities have improved the ability to identify patients who are most likely to benefit from conservative treatment; however, accurate and early identification of those patients who will ultimately require surgical intervention remains a challenge, especially when the clinical symptoms are moderate[2].
SBO is the most frequently encountered surgery-related disorder of the small intestine. In up to two-third of SBO cases, adhesions from prior abdominal surgery are implicated as the direct cause, having manifested as adhesive small bowel obstruction (ASBO)[2,6,8]. Although the majority of ASBO present within one year after surgery, up to 21% can develop up to ten years later[9]. In addition, other causes of SBOs exist, including neoplasma, herniations, inflammatory disease, or congenital disorders. Regardless of the cause, however, obstructed bowel eventually becomes edemateous, which leads to bowel ischemia, inflammation, and necrosis in the end-stage and requires surgical resection.
Patients with SBO usually present with a wide range of complaints, such as nausea, vomiting, and intermittent abdominal pain. In most cases, a history of prior abdominal surgery is present[6,10]. However, the clinical symptoms only contribute partially to diagnosis of ASBO, and studies have calculated the symptom-related sensitivity and specificity of acute abdominal pain as 75% and 99%[11]. One of the more recent studies, evaluating the current diagnostic technologies and clinical routines, found a higher overall sensitivity (88%) but a lower specificity (41%) for this parameter[12]; thus, improved diagnostic modalities are still needed. Unfortunately, the clinical symptoms of SBO are also not reliable predictors of the optimal disease management strategy, and distinguishing patients with bowel strangulation who require prompt surgical intervention remains a particular challenge to clinicians.
Laboratory tests are often used to confirm clinical suspicions and evaluate the degree of illness. The commonly measured inflammatory markers, such as white blood cell (WBC) count and C-reactive protein (CRP)[13], however, cannot distinguish inflammation due to obstruction from other inflammatory syndromes and are therefore of little value in the early diagnosis of ASBO[14]. Even in the case of bowel ischemia, as would be seen in bowel strangulation, studies have detected no significant differences in the WBC or CRP levels of patients who benefit from conservative management and those who require surgical intervention, making these markers useless for distinguishing these two categories of patients[14-16].
When progression to ischemia occurs, L-lactate, lactate dehydrogenase (LDH) and creatine kinase (CK) can rise due to hypoperfusion of the intestinal tissue[15]. However, large quantities of L-lactate are cleared by the liver during splanchnic hypoperfusion, resulting in L-lactate being increased at a very late stage of the process, when extensive intestinal infarction is already well established[17]. From a clinical perspective, a rise in L-lactate level increases sensitivity for detecting bowel ischemia up to 100% and is considered a strong indicator for emergency surgical intervention[18]. In contrast, LDH and CK levels rise in any ischemic condition, and are therefore unspecific. D-dimer, however, may serve as an exclusionary indicator for the presence of ischemia, due to its role as an enzymatic degradation product of fibrin, but it also lacks specificity since it can be elevated in numerous other conditions[14].
Since the above-mentioned markers are not specific enough for diagnosis of SBO they are also not useful for determining whether surgical intervention is needed for any particular case. Instead, these markers can be used to simply reflect severity of the disease and may contribute “circumstantial evidence” to support or deny a decision based upon a wide array of clinical findings.
The 2010 Bologna Guidelines for Diagnosis and Management of ASBO arose from an international consensus statement. According to these guidelines, all suspected cases of ASBO should be evaluated by abdominal X-ray (level 2b)[7]. Specifically, the presence or absence of classical signs, such as distension, > 3 cm diameter dilatation of the small bowel, perturbed air-fluid levels and absence of colonic gas, is considered a sufficient means of diagnosis, and studies have calculated this approach to have overall sensitivity and specificity ranging from 60%-85%[6,7].
In contrast, Laméris et al[12] showed that evaluating patients presenting with acute abdominal pain with plain radiography provided no benefit towards improving the above-mentioned sensitivity and specificity, presuming that there is no role in the diagnostic work-up. Adding ultrasonography (US) after clinical diagnosis, however, was shown to increase the specificity from 41% to 85%. In suspected SBO cases, US can differentiate between ileus and mechanical obstruction, since peristalsis can be observed by this imaging modality[19]. Extra-luminal fluid findings are of major clinical importance as they are commonly used to make clinical decisions as to which surgical approach will be most tolerable and beneficial to a particular patient[20]. In contrast to these findings, the Bologna Guidelines state that there is limited value for US (level 2c), since entrapment of air in ASBO limits ultrasound transmission, making it a useful diagnostic tool only when applied by technical experts[2,7].
Using computed tomography (CT)-scan as an additional imaging platform to evaluate all patients with inconclusive plain radiologic films has proven highly useful for diagnosing SBO[2,7,21,22]. CT-scan has high sensitivity and specificity for SBO (> 92% and 93% respectively); in addition, the additional information provided by CT scanning can help to detect signs of intestinal ischemia or perforation[6,23-25]. However, Maglinte et al[26] reported that CT-scan can be just as sensitive as a plain abdominal x-ray for differentiating between obstruction and non-obstruction (86% vs 82% detection levels). It is important to note that the group with possible signs of ischemia remains a clinical challenge, and making a decision for clinical management is still a problem[10,23,27,28].
Magnetic resonance imaging (MRI) seems to have a limited role in diagnosing ASBO. MRI provides similar sensitivity and specificity as CT-scan, but no current guidelines have been established or implemented for applying MRI in standard clinical practice[2,7,29]. Interestingly, when combining abdominal films with water-soluble contrast medium, the approach can both make a diagnosis and safely rule-out the presence of a complete obstruction. In this manner, patient evaluation by water-soluble contrast studies can help to predict whether their ASBO can be treated conservatively or will require surgical intervention[7,10,22,30]. Besides being a useful diagnostic tool, water-soluble contrast may also have therapeutic potential; its ability to draw fluid into the lumen reduces edema in the gut wall, thereby relieving the obstruction and stimulating peristalsis[31]. A randomized controlled trial by Burge et al[5] showed an appreciable therapeutic effect when gastrografin was applied as the contrast agent to evaluate ASBO patients; specifically, a significantly accelerated resolution of the obstruction was seen in up to 75% of the patients within 24 h after the application. This result may be attributed to the hyperosmolar quality of gastrografin or other contrast mediums. While the precise benefit of contrast mediums reducing the need for surgery have yet to be systematically proven[30,32,33], their relation to reduced length of hospital stay has been demonstrated in several trials[5,28,31,32]. Certainly, however, those ASBO patients who show no contrast being able to enter the colon will require surgical treatment.
The limitations of the above-mentioned diagnostic modalities are likely to cause a delay in diagnosis. In recent years, several serum markers with potential to detect ischemic small bowel have been identified[13,14]. These markers include factors that are released by damaged enterocytes, such as intestinal fatty acid binding protein (I-FABP) and α-glutathione S transferase (α-GST). Enterocytes are rapidly shed in the early phases of intestinal injury and can be readily detected in both urine and plasma, providing promising possibilities for their use as early detection markers[33].
Plasma levels of the cytosolic protein α-GST rise in conjunction with ischemic intestinal damage; yet, this protein provides variable results as a diagnostic tool, with reported sensitivity ranging from 20%-100% and pooled specificity of 85%[14,15,34]. Therefore, α-GST may be more useful as an exclusion criterion, rather then as an indicator for surgical intervention. The other marker I-FABP, a cytosolic protein found in tissues involved in uptake and consumption of fatty acids, is released immediately by damaged small bowel, making it a very specific marker[35]. Patients presenting with SBO but without ischemia show normal levels of serum or urine I-FABP[36]. A recent clinical trial of patients with acute abdominal pain demonstrated that serum I-FABP levels were significantly higher in those patients with small bowel ischemia than in either those with non-ischemic small bowel disease or those without small bowel disease[16]. Furthermore, a majority (57.7%) of these ischemic patients had strangulated bowel. Thus, I-FABP may have a role in selecting candidates for surgical intervention. Other putative candidate markers are D-lactate and claudin[15,37,38]; however, the low specificity of D-lactate and lack of substantial evidence for a role of claudin 3 in SBO makes it difficult to clearly define their potential.
Besides these plasma markers, the prediction model developed by Komatsu et al[39] has identified older age, presence of ascites, and high-volume nasogastral tube drainage on day 3 as critical factors in patients who initially received conservative treatment. Unfortunately, this study did not include findings from radiographic imaging or oral water-soluble studies in the analysis. Although the prediction model is promising, it is necessary to consider the potential impact of markers specifically released by the obstructed small bowel in an earlier stage.
Despite the remarkable technological advances in diagnosis of ASBO, the challenge of determining how to most effectively and safely manage these cases remains. Our ability to identify patients who can be treated conservatively has improved greatly, but the same has not been achieved for patients who will require emergency surgery, especially when their presenting symptoms are moderate. Serum markers have emerged as promising candidates for early diagnosis of strangulated bowel, but further research is necessary to clarify their clinical value in the disease management.
P- Reviewer: Buchs NC S- Editor: Wen LL L- Editor: A E- Editor: Liu XM
1. | Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol. 2011;17:4545-4553. [PubMed] [DOI] [Cited in This Article: ] [Cited by in CrossRef: 281] [Cited by in F6Publishing: 277] [Article Influence: 21.3] [Reference Citation Analysis (2)] |
2. | Diaz JJ, Bokhari F, Mowery NT, Acosta JA, Block EF, Bromberg WJ, Collier BR, Cullinane DC, Dwyer KM, Griffen MM. Guidelines for management of small bowel obstruction. J Trauma. 2008;64:1651-1664. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 71] [Cited by in F6Publishing: 64] [Article Influence: 4.0] [Reference Citation Analysis (0)] |
3. | Takeuchi K, Tsuzuki Y, Ando T, Sekihara M, Hara T, Yoshikawa M, Kuwano H. Clinical studies of strangulating small bowel obstruction. Am Surg. 2004;70:40-44. [PubMed] [Cited in This Article: ] |
4. | Fevang BT, Fevang JM, Søreide O, Svanes K, Viste A. Delay in operative treatment among patients with small bowel obstruction. Scand J Surg. 2003;92:131-137. [PubMed] [Cited in This Article: ] |
5. | Burge J, Abbas SM, Roadley G, Donald J, Connolly A, Bissett IP, Hill AG. Randomized controlled trial of Gastrografin in adhesive small bowel obstruction. ANZ J Surg. 2005;75:672-674. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 53] [Cited by in F6Publishing: 49] [Article Influence: 2.6] [Reference Citation Analysis (0)] |
6. | Kendrick ML. Partial small bowel obstruction: clinical issues and recent technical advances. Abdom Imaging. 2009;34:329-334. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 31] [Cited by in F6Publishing: 35] [Article Influence: 2.3] [Reference Citation Analysis (0)] |
7. | Catena F, Di Saverio S, Kelly MD, Biffl WL, Ansaloni L, Mandalà V, Velmahos GC, Sartelli M, Tugnoli G, Lupo M. Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery. World J Emerg Surg. 2011;6:5. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 93] [Cited by in F6Publishing: 103] [Article Influence: 7.9] [Reference Citation Analysis (0)] |
8. | Attard JA, MacLean AR. Adhesive small bowel obstruction: epidemiology, biology and prevention. Can J Surg. 2007;50:291-300. [PubMed] [Cited in This Article: ] |
9. | Menzies D, Ellis H. Intestinal obstruction from adhesions--how big is the problem? Ann R Coll Surg Engl. 1990;72:60-63. [PubMed] [Cited in This Article: ] |
10. | Wilson MS, Ellis H, Menzies D, Moran BJ, Parker MC, Thompson JN. A review of the management of small bowel obstruction. Members of the Surgical and Clinical Adhesions Research Study (SCAR). Ann R Coll Surg Engl. 1999;81:320-328. [PubMed] [Cited in This Article: ] |
11. | Eskelinen M, Ikonen J, Lipponen P. Contributions of history-taking, physical examination, and computer assistance to diagnosis of acute small-bowel obstruction. A prospective study of 1333 patients with acute abdominal pain. Scand J Gastroenterol. 1994;29:715-721. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 38] [Cited by in F6Publishing: 44] [Article Influence: 1.5] [Reference Citation Analysis (0)] |
12. | Laméris W, van Randen A, van Es HW, van Heesewijk JP, van Ramshorst B, Bouma WH, ten Hove W, van Leeuwen MS, van Keulen EM, Dijkgraaf MG. Imaging strategies for detection of urgent conditions in patients with acute abdominal pain: diagnostic accuracy study. BMJ. 2009;338:b2431. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 248] [Cited by in F6Publishing: 212] [Article Influence: 14.1] [Reference Citation Analysis (0)] |
13. | Derikx JP, Luyer MD, Heineman E, Buurman WA. Non-invasive markers of gut wall integrity in health and disease. World J Gastroenterol. 2010;16:5272-5279. [PubMed] [DOI] [Cited in This Article: ] [Cited by in F6Publishing: 1] [Reference Citation Analysis (0)] |
14. | Block T, Nilsson TK, Björck M, Acosta S. Diagnostic accuracy of plasma biomarkers for intestinal ischaemia. Scand J Clin Lab Invest. 2008;68:242-248. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 107] [Cited by in F6Publishing: 98] [Article Influence: 6.1] [Reference Citation Analysis (0)] |
15. | Evennett NJ, Petrov MS, Mittal A, Windsor JA. Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia. World J Surg. 2009;33:1374-1383. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 152] [Cited by in F6Publishing: 147] [Article Influence: 9.8] [Reference Citation Analysis (0)] |
16. | Kanda T, Tsukahara A, Ueki K, Sakai Y, Tani T, Nishimura A, Yamazaki T, Tamiya Y, Tada T, Hirota M. Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen: a multicenter, observer-blinded validation study. J Gastroenterol. 2011;46:492-500. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 55] [Cited by in F6Publishing: 58] [Article Influence: 4.5] [Reference Citation Analysis (0)] |
17. | Jakob SM, Merasto-Minkkinen M, Tenhunen JJ, Heino A, Alhava E, Takala J. Prevention of systemic hyperlactatemia during splanchnic ischemia. Shock. 2000;14:123-127. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 40] [Cited by in F6Publishing: 44] [Article Influence: 1.8] [Reference Citation Analysis (0)] |
18. | Lange H, Jäckel R. Usefulness of plasma lactate concentration in the diagnosis of acute abdominal disease. Eur J Surg. 1994;160:381-384. [PubMed] [Cited in This Article: ] |
19. | Grassi R, Romano S, D’Amario F, Giorgio Rossi A, Romano L, Pinto F, Di Mizio R. The relevance of free fluid between intestinal loops detected by sonography in the clinical assessment of small bowel obstruction in adults. Eur J Radiol. 2004;50:5-14. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 62] [Cited by in F6Publishing: 49] [Article Influence: 2.5] [Reference Citation Analysis (0)] |
20. | Di Mizio R, Grassi R, Marchese E, Basti M, Di Campli G, Catalano O, Rotondo A, Fanucci A. [“Uncompensated” small bowel obstruction in adults. Ultrasonographic findings of free fluid between loops and its prognostic value]. Radiol Med. 1995;89:787-791. [PubMed] [Cited in This Article: ] |
21. | Obuz F, Terzi C, Sökmen S, Yilmaz E, Yildiz D, Füzün M. The efficacy of helical CT in the diagnosis of small bowel obstruction. Eur J Radiol. 2003;48:299-304. [PubMed] [Cited in This Article: ] |
22. | Trésallet C, Lebreton N, Royer B, Leyre P, Godiris-Petit G, Menegaux F. Improving the management of acute adhesive small bowel obstruction with CT-scan and water-soluble contrast medium: a prospective study. Dis Colon Rectum. 2009;52:1869-1876. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 26] [Cited by in F6Publishing: 29] [Article Influence: 1.9] [Reference Citation Analysis (0)] |
23. | Mallo RD, Salem L, Lalani T, Flum DR. Computed tomography diagnosis of ischemia and complete obstruction in small bowel obstruction: a systematic review. J Gastrointest Surg. 2005;9:690-694. [PubMed] [Cited in This Article: ] |
24. | Zalcman M, Sy M, Donckier V, Closset J, Gansbeke DV. Helical CT signs in the diagnosis of intestinal ischemia in small-bowel obstruction. AJR Am J Roentgenol. 2000;175:1601-1607. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 180] [Cited by in F6Publishing: 142] [Article Influence: 5.9] [Reference Citation Analysis (0)] |
25. | Zielinski MD, Eiken PW, Bannon MP, Heller SF, Lohse CM, Huebner M, Sarr MG. Small bowel obstruction-who needs an operation? A multivariate prediction model. World J Surg. 2010;34:910-919. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 122] [Cited by in F6Publishing: 133] [Article Influence: 9.5] [Reference Citation Analysis (0)] |
26. | Maglinte DD, Reyes BL, Harmon BH, Kelvin FM, Turner WW, Hage JE, Ng AC, Chua GT, Gage SN. Reliability and role of plain film radiography and CT in the diagnosis of small-bowel obstruction. AJR Am J Roentgenol. 1996;167:1451-1455. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 180] [Cited by in F6Publishing: 186] [Article Influence: 6.6] [Reference Citation Analysis (0)] |
27. | Jancelewicz T, Vu LT, Shawo AE, Yeh B, Gasper WJ, Harris HW. Predicting strangulated small bowel obstruction: an old problem revisited. J Gastrointest Surg. 2009;13:93-99. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 86] [Cited by in F6Publishing: 78] [Article Influence: 5.2] [Reference Citation Analysis (0)] |
28. | Wadani HA, Al Awad NI, Hassan KA, Zakaria HM, Alaqeel FO. Role of water soluble contrast agents in assigning patients to a non-operative course in adhesive small bowel obstruction. Oman Med J. 2011;26:454-456. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 10] [Cited by in F6Publishing: 12] [Article Influence: 1.0] [Reference Citation Analysis (0)] |
29. | Fidler J. MR imaging of the small bowel. Radiol Clin North Am. 2007;45:317-331. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 100] [Cited by in F6Publishing: 76] [Article Influence: 4.5] [Reference Citation Analysis (0)] |
30. | Branco BC, Barmparas G, Schnüriger B, Inaba K, Chan LS, Demetriades D. Systematic review and meta-analysis of the diagnostic and therapeutic role of water-soluble contrast agent in adhesive small bowel obstruction. Br J Surg. 2010;97:470-478. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 144] [Cited by in F6Publishing: 138] [Article Influence: 9.9] [Reference Citation Analysis (0)] |
31. | Di Saverio S, Catena F, Ansaloni L, Gavioli M, Valentino M, Pinna AD. Water-soluble contrast medium (gastrografin) value in adhesive small intestine obstruction (ASIO): a prospective, randomized, controlled, clinical trial. World J Surg. 2008;32:2293-2304. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 90] [Cited by in F6Publishing: 96] [Article Influence: 6.4] [Reference Citation Analysis (0)] |
32. | Abbas SM, Bissett IP, Parry BR. Meta-analysis of oral water-soluble contrast agent in the management of adhesive small bowel obstruction. Br J Surg. 2007;94:404-411. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 78] [Cited by in F6Publishing: 87] [Article Influence: 5.1] [Reference Citation Analysis (0)] |
33. | Derikx JP, Matthijsen RA, de Bruïne AP, van Bijnen AA, Heineman E, van Dam RM, Dejong CH, Buurman WA. Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation. PLoS One. 2008;3:e3428. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 73] [Cited by in F6Publishing: 82] [Article Influence: 5.1] [Reference Citation Analysis (0)] |
34. | Delaney CP, O’Neill S, Manning F, Fitzpatrick JM, Gorey TF. Plasma concentrations of glutathione S-transferase isoenzyme are raised in patients with intestinal ischaemia. Br J Surg. 1999;86:1349-1353. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 39] [Cited by in F6Publishing: 39] [Article Influence: 1.6] [Reference Citation Analysis (0)] |
35. | Lieberman JM, Sacchettini J, Marks C, Marks WH. Human intestinal fatty acid binding protein: report of an assay with studies in normal volunteers and intestinal ischemia. Surgery. 1997;121:335-342. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 156] [Cited by in F6Publishing: 162] [Article Influence: 6.0] [Reference Citation Analysis (0)] |
36. | Kanda T, Fujii H, Tani T, Murakami H, Suda T, Sakai Y, Ono T, Hatakeyama K. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. Gastroenterology. 1996;110:339-343. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 177] [Cited by in F6Publishing: 173] [Article Influence: 6.2] [Reference Citation Analysis (0)] |
37. | Thuijls G, Derikx JP, de Haan JJ, Grootjans J, de Bruïne A, Masclee AA, Heineman E, Buurman WA. Urine-based detection of intestinal tight junction loss. J Clin Gastroenterol. 2010;44:e14-e19. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 52] [Cited by in F6Publishing: 58] [Article Influence: 4.1] [Reference Citation Analysis (0)] |
38. | van Noord D, Mensink PB, de Knegt RJ, Ouwendijk M, Francke J, van Vuuren AJ, Hansen BE, Kuipers EJ. Serum markers and intestinal mucosal injury in chronic gastrointestinal ischemia. Dig Dis Sci. 2011;56:506-512. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 22] [Cited by in F6Publishing: 22] [Article Influence: 1.7] [Reference Citation Analysis (0)] |
39. | Komatsu I, Tokuda Y, Shimada G, Jacobs JL, Onodera H. Development of a simple model for predicting need for surgery in patients who initially undergo conservative management for adhesive small bowel obstruction. Am J Surg. 2010;200:215-223. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 19] [Cited by in F6Publishing: 29] [Article Influence: 2.1] [Reference Citation Analysis (0)] |