Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges

doi:10.3748/wjg.v32.i5.115439

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Feb 7, 2026 (publication date) through Jan 28, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2026; 32(5): 115439
Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.115439

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Figure 1 Mechanism of growth differentiation factor 15. Growth differentiation factor 15 (GDF15) binds to its receptor glial cell line derived neurotrophic factor-family receptor α-like, which forms a signaling complex with the co-receptor rearranged during transfection on the cell membrane. Ligand-receptor engagement activates downstream intracellular signal-transduction pathways, mediating the biological effects of GDF15. IL: Interleukin; TNF-α: Tumor necrosis factor α; CDF15: Growth differentiation factor 15; GFRAL: Glial cell line derived neurotrophic factor-family receptor α-like; RET: Rearranged during transfection.

Citation: Yang J, Pan YT, Wen HZ. Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges. World J Gastroenterol 2026; 32(5): 115439
URL: https://www.wjgnet.com/1007-9327/full/v32/i5/115439.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i5.115439